Figure 3

Time depandant increase in survival in recombinant human erythropoietin-treated mice with cerebral malaria. Time dependant increase in survival in mice with CM treated with recombinant human Erythropoietin (rhEpo): The cumulative survival analysis of mice ECM treated with 100 U daily of rhEpo show increased survival at the end of the second week only in mice treated from day 4–7 (42.9%, p < 0.001 vs. vehicle). The other treatment schemes used (day 1–4; day 7–10; day 1–7) and mice that received treatment from day 1–7 and where bleed for 10% of their total blood volume to prevent excessively high levels of packed cell volume did not show a statistically significant increase in survival. Statistical test: log rank statistic for the survival curves with pair wise comparison using the Holm-Sidak method.