Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine

Table 5 Demographic, clinical and parasitological characteristics of baseline isolates from recrudescent and non-recrudescent patients (Tsiroanomandidy, Madagascar, 2006).

	Patients
	Recrudescent			Non-Recrudescent			P
	No	Value	CI95%	No	Value	CI95%
Patient charasteristics
No of males/No of females	3	3/0	-	11	4/7	-
Age (years), mean	3	5.3	0 – 15.6	11	14.7	5.3–24.0	NS
Temperature (°C), mean	3	38.8	35.8–41.9	11	38.0	37.6–38.4	NS
Hematology
Hemoglobin concentration (g/dL), mean	3	6.8	5.5 – 8.1	11	7,5	5.1–9.9	NS
Isolates at the baseline
Parasitemia (parasites/μL), geometric mean	3	3434	361 – 32627	11	3307	1603–6823	NS
Mean number of mutations in dhfr/dhps genes	3	2.3	1.6–3	11	1.4	0.6–2.2	NS

One patient presenting a P. falciparum infection and the one presenting a P. vivax reinfection (or relapse, as indicated by genotyping analysis) were excluded from the non-recrudescent patients group.

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