Figure 2

Log plasma biomarker levels and disease severity. Log median levels (pg/ml) of eighteen (18) biomarkers [IFN-γ, TNF-α, MIP-1α, IL-1β, IL-2, RANTES, IL-4, IL-5, G-CSF, IL-6, IL-9, Eotaxin, IL-12 (p70), IL-13, GM-CSF, IL-15, IL-17 and MCP-1 (MCAF)]. Biomarkers were quantified via Luminex™ from blood samples collected from patients at time of admission. HC – healthy controls, MM – mild malaria, CMS – cerebral malaria survivors, CMNS – cerebral malaria non-survivors. Box plots represent medians and 25^th and 75^th percentiles. Bars mark the 10^th and 90^th percentiles, and outliers are plotted as points. HC versus MM, CMS, and CMNS: *** p < 0.05, $$$ p < 0.0045 bonferroni adjustment (alpha = 0.05/18)