Table 2 Motifs within Plasmodium spp. MRP nucleotide binding domains
Nucleotide Binding Domain | Motif | Consensus Sequence | Consensus in Plasmodium spp. | Location in pbMRP |
|---|---|---|---|---|
NBD1 | Walker A | GxxxxGK [S, T] | G [D, N] [I, V]GSG [E, K]T | 714–722 |
|  | Q loop | XQx | PQ [I, F] | 753–755 |
|  | ABC motif | LSGGQ | LSKGQ | 808–812 |
|  | Walker B | XILxDE | LYL [L, F]DD | 954–959 |
|  | D loop | LD | LD | 964–965 |
| Â | H loop | XHx | Not identified | Â |
NBD2 | Walker A | GxxxxGK [S, T] | G [K, R]SGAGKS | 1705–1712 |
|  | Q loop | XQx | PQS | 1752–1754 |
|  | ABC motif | LSGGQ | L [S, A]LVR | 1835–1839 |
|  | Walker B | XILxDE | L [L, V, I]LIDE | 1849–1854 |
| Â | D loop | LD | Not identified | Â |
|  | H loop | XHx | [S, A]HD | 1895–1897 |