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Table 3 OHCT (nM) inhibits growth of P. falciparum gametocytes*

From: Antimalarial activity of a cis-terpenone

OHCT

(Stage I and II)

Chloroquine

(Stage I and II)

OHCT

(Stage III and IV)

Chloroquine

(Stage III and IV)

(IC 50 ) 22 ± 3.4

394 ± 127.0

36 ± 9.0

944 ± 92.0

(IC 90 ) 174 ± 5.4

1520 ± 27.5

226 ± 49.3

2109 ± 85.2

  1. *IC50 and IC90 values (nM) represent the mean ± SE of duplicate experiments, each performed in duplicate (vehicle and 8 concentrations per experiment