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Table 2 Select Gene Expression Changes Mediated by 15-HETEa

From: Differential gene expression mediated by 15-hydroxyeicosatetraenoic acid in LPS-stimulated RAW 264.7 cells

Gene Symbol Fold Change Probe ID Description Entrez ID Ref
Electron Transport [21]
Cyp3a11 3.6 516253 Cytochrome P450, family 3, subfamily a, polypeptide 11 13112  
Smox 5.1 560410 Spermine oxidase 228608  
Ugdh 1.9 500013 UDP-glucose dehydrogenase 22235  
Regulation of Transcription, DNA-Dependent [21]
Bclaf1 -1.9 549609 BCL2-associated transcription factor 1 72567  
Cdk9 2.1 392872 Cyclin-dependent kinase 9 (CDC2-related kinase) 107951  
Creg1 1.9 760346 Cellular repressor of E1A-stimulated genes 1 433375  
Egr1 -4.7 524988 Early growth response 1 13653  
Fbxl11 -2.9 464056 F-box and leucine-rich repeat protein 11 225876  
Fli1 2.3 407869 Friend leukemia integration 1 14247  
Fliih 4.6 706377 Flightless I homologue (Drosophila) 14248  
Hlx1 2.1 915372 H2.0-like homeo box 1 (Drosophila) 15284  
Mxd1 2.1 520449 MAX dimerization protein 1 17119  
Myst2 5.4 494053 MYST histone acetyltransferase 2 217127  
Pou2f2 -4.4 911620 POU domain, class 2, transcription factor 2 18987  
Pparbp 1.9 553770 Peroxisome proliferator activated receptor binding protein 19014  
Pspc1 2.0 474771 Paraspeckle protein 1 66645  
Rab11a 2.0 359489 RAB11a, member RAS oncogene family 53869  
Rnf4 2.5 567180 Ring finger protein 4 19822  
Tsc22d3 2.0 700170 TSC22 domain family 3 14605  
Zfp482 2.0 435236 Zinc finger protein 482 241322  
Protein Biosynthesis [20, 21]
Eprs 4.9 455664 Glutamyl-prolyl-tRNA synthetase 107508  
Protein Folding [21]
Clpx 2.4 733670 Caseinolytic peptidase X (E. coli) 270166  
Hspa4 3.5 578003 Heat shock protein 4 15525  
Ubiquitin Cycle [21]
Cul7 0.4 742757 Cullin 7 66515  
Fbxo3 1.9 832607 F-box only protein 3 57443  
Ube2l6 2.0 401185 Ubiquitin-conjugating enzyme E2L 6 56791 [16]
Intracellular Protein Transport [21]
Ap1s2 2.0 605927 Adaptor-related protein complex 1, sigma 2 subunit 108012  
Arf3 4.4 652348 ADP-ribosylation factor 3 11842  
Sort1 2.4 339169 Sortilin 1 20661  
Response to Stress [21]
Mapk14 2.2 755610 Mitogen activated protein kinase 14 26416 [16]
Prdx1 2.1 530413 Peroxiredoxin 1 18477 [17]
Prdx6 -2.0 825043 Peroxiredoxin 6 11758  
Defense Response [20, 21]
Bst1 2.1 837914 Bone marrow stromal cell antigen 1 12182  
Klra18 2.5 806675 Killer cell lectin-like receptor, subfamily A, member 18 93970  
Tapbp 2.0 928057 TAP binding protein 21356 [20]
Inflammatory Response [20, 21]
Abcb1a 2.6 677412 ATP binding cassette, sub-family B (MDR/TAP), member 1A 97570  
Ca2 4.0 574832 Carbonic anhydrase 2 88269  
Card12 2.2 336709 Caspase recruitment domain family, member 12 268973  
Cdkn1b 3.7 516253 Cytochrome P450, family 3, subfamily a, polypeptide 11 104565  
Clu 4.0 379462 Clusterin 88423  
Cr1l 1.9 538208 Complement component (3b/4b) receptor 1-like 88513  
Cyp3a11 3.7 516253 Cytochrome P450, family 3, subfamily a, polypeptide 11 88609  
Fyn 2.50 766362 Fyn proto-oncogene 95602  
H2-Q8 1.8 712519 Histocompatibility 2, Q region locus 8 95937  
Hnrnpa3 4.8 903894 Heterogeneous nuclear ribonucleoprotein A3 1917171  
Mrc1 2.9 331550 Mannose receptor, C type 1 97142  
Pole4 2.3 508321 Polymerase (DNA-directed), ε 4 (p12 subunit) 1914229  
Ppp3r1 2.7 716541 Protein phospatase 3, regulatory subunit B, α isoform (calcineurin B, type I) 107172  
Procr 2.0 431405 Protein C receptor, endothelial 104596  
Rrm1 5.6 865694 Ribonucleotide reductase M1 98180  
Serpinb2 4.0 860577 Serine (or cysteine) proteinase inhibitor, clade B, member 2 97609  
Leukocyte Extravasation and Signalling
Arhgap12 2.2 465731 ρ GTPase activating protein 12 1922665  
Crkl 3.0 389169 V-crk sarcoma virus CT10 oncogene homologue (avian)-like 104686  
Ptk2b 2.6 867483 PTK2 protein tyrosine kinase 2 β 104908  
Immune Response [20, 21]
Cxcl11 5.1 921243 Chemokine (C-X-C motif) ligand 11 56066  
Ddx58 7.1 438990 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 230073  
Fcgrt 2.0 390657 Fc receptor, IgG, α chain transporter 14132 [16]
Gbp1 2.9 586296 Guanylate nucleotide binding protein 1 14468 [16, 18, 20]
Gbp3 3.0 405120 Guanylate nucleotide binding protein 3 55932 [17, 20]
Ifit3 3.2 888038 Interferon-induced protein with tetratricopeptide repeats 3 15959  
Il1a 5.1 595893 Interleukin 1 α 96542  
Il1b 2.4 734612 Interleukin 1 β 16176  
Il15 1.9 876196 Interleukin 15 16168  
Cell Cycle [20]
Ccnf 2.4 767163 Cyclin F 12449  
Cdkn1b 3.7 704876 Cyclin-dependent kinase inhibitor 1B (P27) 12576  
Pmp22 1.9 616997 Peripheral myelin protein 18858  
Rhob -2.2 925472 Ras homologue gene family, member B 11852  
Cell Adhesion [21]
Cldn11 4.9 338333 Claudin 11 18417  
Scarb2 2.5 561450 Scavenger receptor class B, member 2 12492  
Tnfaip6 1.9 614886 Tumor necrosis factor alpha induced protein 6 21930 [16]
Signal Transduction [20]
Ccr4 2.2 618105 Chemokine (C-C motif) receptor 4 12773 [18]
Cd86 3.2 908805 Cd86 antigen 12524 [20, 22]
Gnas 1.8 646267 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 14683  
Ms4a4c 2.8 791872 495283 Membrane-spanning 4-domains, subfamily A, member 4C 64380  
Olfr472 -2.2 591718 Olfactory receptor 472 258770  
Prkrir 3.4 561755 Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) 72981  
Ptger2 3.0 912597 Prostaglandin E receptor 2 (subtype EP2) 19217  
Rin1 -1.9 478326 Ras and Rab interactor 1 225870  
Ywhag 4.1 606287 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 22628  
G-Protein Coupled Receptor Protein Signaling Pathway [21]
Olfr1303 -2.0 366625 Olfactory receptor 1303 258397  
Olfr316 -1.9 903210 Olfactory receptor 316 258064  
Olfr435 -3.2 810459 Olfactory receptor 435 258647  
Slc19a2 1.9 763767 Solute carrier family 19 (thiamine transporter), member 2 116914  
Cell-Cell Signaling [21]
Wnt6 2.0 590115 Wingless-related MMTV integration site 6 22420  
Development [21]
Egfl4 -2.2 914308 EGF-like-domain, multiple 4 269878  
Lrp6 -2.3 691244 Low density lipoprotein receptor-related protein 6 16974  
Pgf 2.9 932795 Placental growth factor 18654  
Metabolism [20]
Atp1a2 2.1 684165 ATPase, Na+/K+ transporting, α 2 polypeptide 98660  
Atp2c1 2.0 388850 ATPase, Ca2+ sequestering 235574  
Echdc3 2.2 331450 Enoyl Coenzyme A hydratase domain containing 3 67856  
Hsd17b4 2.2 303973 Hydroxysteroid (17-beta) dehydrogenase 4 15488  
Mmp9 -12.3 710293 Matrix metalloproteinase 9 17395  
Oas3 -3.0 487213 2'-5' oligoadenylate synthetase 3 246727 [16]
Carbohydrate Transport [21]
Slc35a4 2.5 318829 Solute carrier family 35, member A4 67843  
Protein Transport [21]
Exoc2 3.0 498825 Exocyst complex component 2 66482  
Nupl2 2.1 868036 Nucleoporin like 2 231042  
Rab20 2.0 410549 RAB20, member RAS oncogene family 19332  
Rap2b 2.2 471908 RAP2B, member of RAS oncogene family 74012  
Rheb 1.9 653270 RAS-homologue enriched in brain 19744  
Zfyve20 2.9 669220 Zinc finger, FYVE domain containing 20 78287  
Protein Ubiquitination [21]
Trim12 2.7 454451 Tripartite motif protein 12 76681  
Trim34 2.9 600486 Tripartite motif protein 34 94094  
Differentiation [21]
Ndrg2 2.1 468211 N-myc downstream regulated gene 2 29811  
Other
Pik3ap1 2.0 646764 Phosphoinositide-3-kinase adaptor protein 1 83490 [16]
  1. aTranscripts altered ≥ 1.8-fold (p ≤ 0.025) in 15(S)-HETE-treated RAW 264.7 cells that are associated with specific genes or gene products correlated to malaria (referenced in column 6) or genes that are classified with specific over-expressed GO biological processes in malaria models (referenced with biological process heading), are shown in the table. Fold changes (FC) represent the average of three independent biological experiments. Bold FC indicate that multiple probes gave analogous results (average FC is shown).