SNP rs#
|
Gene
|
Allelic state
|
Frequency of derived allele
|
Association P value
|
---|
Ancestral
|
Derived
|
Severe malaria
|
Mild malaria
|
Raw
|
Permutation
|
---|
rs162887
|
SLC22A4
|
C
|
T
|
0.369
|
0.402
|
0.381
|
1.000
|
rs3792876
|
SLC22A4
|
C
|
T
|
0.234
|
0.236
|
0.944
|
1.000
|
rs3792878
|
SLC22A4
|
G
|
A
|
0.954
|
0.932
|
0.235
|
0.996
|
rs3805665
|
SLC22A4
|
G
|
A
|
0.23
|
0.237
|
0.823
|
1.000
|
rs3805668
|
SLC22A4
|
G
|
A
|
0.229
|
0.236
|
0.818
|
1.000
|
rs270608
|
SLC22A4
|
A
|
G
|
0.338
|
0.379
|
0.328
|
1.000
|
rs270607
|
SLC22A4
|
C
|
T
|
0.372
|
0.397
|
0.515
|
1.000
|
rs2073839
|
SLC22A4
|
C
|
T
|
0.234
|
0.236
|
0.950
|
1.000
|
rs3828673
|
SLC22A4
|
G
|
A
|
0.234
|
0.236
|
0.950
|
1.000
|
rs3792885
|
SLC22A4
|
A
|
T
|
0.229
|
0.236
|
0.818
|
1.000
|
rs272842
|
SLC22A4
|
T
|
C
|
0.348
|
0.299
|
0.181
|
0.985
|
rs3761659
|
SLC22A4
|
C
|
G
|
0.234
|
0.236
|
0.950
|
1.000
|
rs3805673
|
SLC22A4
|
G
|
A
|
0.228
|
0.237
|
0.771
|
1.000
|
rs273915
|
SLC22A4
|
G
|
C
|
0.375
|
0.397
|
0.563
|
1.000
|
rs272887
|
SLC22A4
|
C
|
T
|
0.372
|
0.397
|
0.515
|
1.000
|
rs273909
|
SLC22A4
|
T
|
C
|
0.071
|
0.093
|
0.307
|
1.000
|
rs272879
|
SLC22A4
|
G
|
C
|
0.344
|
0.297
|
0.201
|
0.992
|
rs272873
|
SLC22A4
|
C
|
T
|
0.167
|
0.175
|
0.773
|
1.000
|
rs2306772
|
SLC22A4
|
G
|
A
|
0.234
|
0.236
|
0.950
|
1.000
|
rs272867
| |
C
|
T
|
0.344
|
0.298
|
0.205
|
0.992
|
rs3788987
|
SLC22A5
|
G
|
A
|
0.232
|
0.238
|
0.843
|
1.000
|
rs2631362
|
SLC22A5
|
T
|
C
|
0.365
|
0.376
|
0.769
|
1.000
|
rs2631359
|
SLC22A5
|
G
|
A
|
0.363
|
0.379
|
0.671
|
1.000
|
rs4646301
|
SLC22A5
|
G
|
A
|
0.236
|
0.253
|
0.614
|
1.000
|
rs274571
|
SLC22A5
|
T
|
C
|
0.365
|
0.379
|
0.719
|
1.000
|
rs2073642
|
SLC22A5
|
C
|
T
|
0.241
|
0.254
|
0.707
|
1.000
|
rs183898
|
SLC22A5
|
G
|
C
|
0.361
|
0.381
|
0.597
|
1.000
|
rs4646305
|
SLC22A5
|
G
|
A
|
0.237
|
0.251
|
0.678
|
1.000
|
rs274559
|
SLC22A5
|
C
|
T
|
0.348
|
0.299
|
0.181
|
0.985
|
rs274558
|
SLC22A5
|
C
|
T
|
0.353
|
0.299
|
0.144
|
0.965
|
rs274554
|
SLC22A5
|
A
|
G
|
0.837
|
0.887
|
0.059
|
0.748
|
rs274553
|
SLC22A5
|
G
|
C
|
0.163
|
0.113
|
0.059
|
0.748
|
rs274551
|
SLC22A5
|
C
|
T
|
0.161
|
0.113
|
0.072
|
0.804
|
rs274549
|
SLC22A5
|
G
|
T
|
0.163
|
0.113
|
0.059
|
0.748
|
rs274547
|
SLC22A5
|
T
|
A
|
0.839
|
0.887
|
0.072
|
0.804
|
rs2285673
|
LOC441108
|
C
|
T
|
0.227
|
0.199
|
0.388
|
1.000
|
rs2269822
|
LOC441108
|
Cb
|
T
|
0.282
|
0.281
|
1.000
|
1.000
|
rs3749834
| |
C
|
T
|
0.236
|
0.238
|
0.929
|
1.000
|
rs2070730
|
IRF1
|
C
|
T
|
0.418
|
0.407
|
0.765
|
1.000
|
rs2070727
|
IRF1
|
G
|
T
|
0.42
|
0.406
|
0.725
|
1.000
|
rs2070723
|
IRF1
|
C
|
T
|
0.582
|
0.593
|
0.765
|
1.000
|
rs2070722
|
IRF1
|
G
|
T
|
0.596
|
0.587
|
0.823
|
1.000
|
rs739718a
| |
A
|
G
|
0.257
|
0.261
|
0.903
|
1.000
|
rs2069812a
|
IL5
|
T
|
C
|
0.241
|
0.302
|
0.083
|
0.848
|
rs2299015
|
RAD50
|
A
|
C
|
0.111
|
0.186
|
0.008
|
0.193
|
rs2299014
|
RAD50
|
T
|
G
|
0.074
|
0.07
|
0.838
|
1.000
|
rs2243677
|
RAD50
|
G
|
A
|
0.887
|
0.804
|
0.004
|
0.107
|
rs2522414
|
RAD50
|
G
|
C
|
0.887
|
0.804
|
0.004
|
0.107
|
rs2299013
|
RAD50
|
Cc
|
G
|
0.104
|
0.186
|
0.004
|
0.101
|
rs2252775
|
RAD50
|
A
|
C
|
0.11
|
0.186
|
0.007
|
0.174
|
rs2522394
|
RAD50
|
A
|
G
|
0.887
|
0.804
|
0.004
|
0.107
|
rs2245460
|
RAD50
|
A
|
T
|
0.112
|
0.189
|
0.006
|
0.160
|
rs2301713
|
RAD50
|
T
|
C
|
0.113
|
0.186
|
0.010
|
0.242
|
rs3798135
|
RAD50
|
G
|
A
|
0.113
|
0.186
|
0.010
|
0.242
|
rs2237060
|
RAD50
|
A
|
C
|
0.04
|
0.055
|
0.351
|
1.000
|
rs2074369
|
RAD50
|
C
|
T
|
0.883
|
0.804
|
0.006
|
0.158
|
rs2240032
|
RAD50
|
C
|
T
|
0.106
|
0.183
|
0.006
|
0.152
|
rs1881457
|
IL13
|
A
|
C
|
0.124
|
0.219
|
0.002
|
0.046d
|
rs1800925
|
IL13
|
T
|
C
|
0.894
|
0.826
|
0.014
|
0.296
|
rs2066960
|
IL13
|
A
|
C
|
0.628
|
0.636
|
0.830
|
1.000
|
rs20541a
|
IL13
|
C
|
T
|
0.33
|
0.389
|
0.115
|
0.924
|
rs2070874
|
IL4
|
T
|
C
|
0.273
|
0.274
|
0.975
|
1.000
|
rs2243270
|
IL4
|
G
|
A
|
0.263
|
0.266
|
0.913
|
1.000
|
rs2243289
|
IL4
|
A
|
G
|
0.729
|
0.736
|
0.825
|
1.000
|
rs1468215
|
KIF3A
|
T
|
A
|
0.26
|
0.247
|
0.725
|
1.000
|
rs3798132
|
KIF3A
|
A
|
G
|
0.352
|
0.336
|
0.685
|
1.000
|
rs3798130
|
KIF3A
|
G
|
A
|
0.671
|
0.677
|
0.882
|
1.000
|
rs2299007
|
KIF3A
|
T
|
C
|
0.383
|
0.431
|
0.219
|
0.994
|
rs2237057
|
KIF3A
|
T
|
C
|
0.742
|
0.75
|
0.818
|
1.000
|
rs2299006
|
KIF3A
|
G
|
C
|
0.654
|
0.667
|
0.738
|
1.000
|
rs2299005
|
KIF3A
|
T
|
C
|
0.661
|
0.668
|
0.836
|
1.000
|
rs3798129
|
KIF3A
|
A
|
T
|
0.336
|
0.337
|
0.975
|
1.000
|
rs3756754
|
KIF3A
|
C
|
T
|
0.022
|
0.013
|
0.366
|
1.000
|
rs256871
|
SEPT8
|
C
|
T
|
0.609
|
0.635
|
0.490
|
1.000
|
rs30534
|
SEPT8
|
G
|
A
|
0.391
|
0.365
|
0.490
|
1.000
|
rs30533
|
SEPT8
|
T
|
C
|
0.386
|
0.371
|
0.686
|
1.000
|
rs39588
|
SEPT8
|
C
|
G
|
0.383
|
0.369
|
0.717
|
1.000
|
rs256875
|
SEPT8
|
T
|
C
|
0.385
|
0.379
|
0.888
|
1.000
|
rs392916
|
SEPT8
|
T
|
A
|
0.532
|
0.561
|
0.459
|
1.000
|
rs30527
|
SEPT8
|
C
|
T
|
0.62
|
0.639
|
0.620
|
1.000
|
rs30524
|
SEPT8
|
G
|
T
|
0.383
|
0.362
|
0.573
|
1.000
|
rs757537
|
ANKRD43
|
T
|
C
|
0.131
|
0.157
|
0.357
|
1.000
|
- a SNP genotyped by TaqMan assay.
- b Allelic state could not be inferred.
- c Allelic state inferred based on the sequence of rhesus macaque.
- d Permutation P value < 0.05.