Table 2 Optimal biomarker cut-off values for receiver operating characteristic curve sensitivity, specificity, positive likelihood ratio (LR(+)) and negative likelihood ratio (LR(-)) at the chosen cutoffs.
| Â | Cut-off | Sensitivity | Specificity | LR(+) | LR(-) |
|---|---|---|---|---|---|
Angiopoietin-2 | ng/mL | # (95% CI) | # (95% CI) | # (95% CI) | # (95% CI) |
UM vs. SM | 1.43 | 0.694 (0.531-0.820) | 0.786 (0.676-0.866) | 3.241 (1.969-5.333) | 0.389 (0.234-0.646) |
UM vs. CM | 1.33 | 0.759 (0.659-0.836) | 0.771 (0.661-0.854) | 3.319 (2.124-5.186) | 0.313 (0.211-0.464) |
UM vs. (CM+SM) | 1.33 | 0.740 (0.656-0.809) | 0.771 (0.661-0.854) | 3.237 (2.078-5.041) | 0.337 (0.244-0.466) |
SM vs. CM | 3.14 | 0.472 (0.319-0.630) | 0.644 (0.539-0.736) | 1.325 (0.848-2.070) | 0.820 (0.580-1.159) |
Angiopoietin-1 | ng/mL | # (95% CI) | # (95% CI) | # (95% CI) | # (95% CI) |
UM vs. SM | 12.38 | 0.861 (0.713-0.939) | 0.852 (0.757-0.921) | 6.028 (3.346- 10.859) | 0.162 (0.071-0.368) |
UM vs. CM | 15.86 | 0.713 (0.610-0.797) | 0.743 (0.630-0.831) | 2.771 (1.821-4.218) | 0.387 (0.270-0.554) |
UM vs. (CM+SM) | 15.16 | 0.707 (0.622-0.781) | 0.771 (0.661-0.854) | 3.094 (1.983-4.830) | 0.379 (0.280-0.514) |
SM vs. CM | 11.21 | 0.722 (0.560-0.842) | 0.655 (0.551-0.747) | 2.094 (1.471-2.982) | 0.424 (0.245-0.734) |
Ratio | Â | # (95% CI) | # (95% CI) | # (95% CI) | # (95% CI) |
UM vs. SM | 0.082 | 0.806 (0.650-0.903) | 0.829 (0.724-0.899) | 4.699 (2.74-8.059) | 0.235 (0.120-0.460) |
UM vs. CM | 0.080 | 0.782 (0.684-0.856) | 0.829 (0.724-0.899) | 4.559 (2.692-7.722) | 0.264 (0.175-0.398) |
UM vs. (CM+SM) | 0.080 | 0.789 (0.708-0.852) | 0.829 (0.723-0.899) | 4.600 (2.727-7.762) | 0.255 (0.178-0.365) |
SM vs. CM | 0.448 | 0.444 (0.295-0.604) | 0.828 (0.735-0.893) | 2.578 (1.432-4.639) | 0.671 (0.494-0.913) |