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Table 2 Optimal biomarker cut-off values for receiver operating characteristic curve sensitivity, specificity, positive likelihood ratio (LR(+)) and negative likelihood ratio (LR(-)) at the chosen cutoffs.

From: Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria

  Cut-off Sensitivity Specificity LR(+) LR(-)
Angiopoietin-2 ng/mL #
(95% CI)
#
(95% CI)
#
(95% CI)
#
(95% CI)
UM vs. SM 1.43 0.694
(0.531-0.820)
0.786
(0.676-0.866)
3.241
(1.969-5.333)
0.389
(0.234-0.646)
UM vs. CM 1.33 0.759
(0.659-0.836)
0.771
(0.661-0.854)
3.319
(2.124-5.186)
0.313
(0.211-0.464)
UM vs. (CM+SM) 1.33 0.740
(0.656-0.809)
0.771
(0.661-0.854)
3.237
(2.078-5.041)
0.337
(0.244-0.466)
SM vs. CM 3.14 0.472
(0.319-0.630)
0.644
(0.539-0.736)
1.325
(0.848-2.070)
0.820
(0.580-1.159)
Angiopoietin-1 ng/mL #
(95% CI)
#
(95% CI)
#
(95% CI)
#
(95% CI)
UM vs. SM 12.38 0.861
(0.713-0.939)
0.852
(0.757-0.921)
6.028 (3.346- 10.859) 0.162
(0.071-0.368)
UM vs. CM 15.86 0.713
(0.610-0.797)
0.743
(0.630-0.831)
2.771
(1.821-4.218)
0.387
(0.270-0.554)
UM vs. (CM+SM) 15.16 0.707
(0.622-0.781)
0.771
(0.661-0.854)
3.094
(1.983-4.830)
0.379
(0.280-0.514)
SM vs. CM 11.21 0.722
(0.560-0.842)
0.655
(0.551-0.747)
2.094
(1.471-2.982)
0.424
(0.245-0.734)
Ratio   #
(95% CI)
#
(95% CI)
#
(95% CI)
#
(95% CI)
UM vs. SM 0.082 0.806
(0.650-0.903)
0.829
(0.724-0.899)
4.699
(2.74-8.059)
0.235
(0.120-0.460)
UM vs. CM 0.080 0.782
(0.684-0.856)
0.829
(0.724-0.899)
4.559
(2.692-7.722)
0.264
(0.175-0.398)
UM vs. (CM+SM) 0.080 0.789
(0.708-0.852)
0.829
(0.723-0.899)
4.600
(2.727-7.762)
0.255
(0.178-0.365)
SM vs. CM 0.448 0.444
(0.295-0.604)
0.828
(0.735-0.893)
2.578
(1.432-4.639)
0.671
(0.494-0.913)