Table 2 TLR2, 4, 9, and MAL genotypes in various populations
From: Toll-like receptor polymorphisms in malaria-endemic populations
| Â | PNG | Kenya | North America | ||||
|---|---|---|---|---|---|---|---|
PolymorphismI | genotype | lowlands | lowlands | highlands | African | Caucasian | Asian |
TLR2 Δ22 | WW | 253(76) | 41(49) | 33(48) | 58(62) | 64(76) | 49(58) |
| Â | WDII | 73(22) | 36(43) | 27(39) | 30(32) | 18(21) | 27(32) |
| Â | DD | 7(2) | 7(8) | 9(13) | 5(5) | 2(2) | 8(10) |
TLR4 Asp299Gly | Asp/Asp | 906(100)IV | 78(86) | 66(89) | 65(74) | 67(83) | 76(92) |
| Â | Asp/Gly | 0 | 13(14) | 8(11) | 23(26) | 14(17) | 7(8) |
TLR4 Thr399Ile | Thr/Thr | 906(100)IV | 64(97) | 69(99) | 84(94) | 64(81) | 77(93) |
| Â | Thr/Ile | 0 | 2(3) | 1(1) | 5(6) | 15(19) | 6(7) |
TLR9 -1486 | TT | 137(41) | 47(54) | 41(54) | 37(42) | 36(44) | 34(41) |
| Â | CT | 146(44) | 33(38) | 32(42) | 43(48) | 35(43) | 38(46) |
| Â | CC | 51(15) | 7(8) | 3(4) | 9(10) | 10(12) | 11(13) |
TLR9 -1237 | TT | 334(100) | 39(45) | 29(38) | 36(40) | 61(75) | 74(89) |
| Â | CT | 0 | 35(40) | 39(51) | 46(52) | 19(23) | 7(8)III |
| Â | CC | 0 | 13(15) | 8(11) | 7(8) | 1(1) | 2(2) |
TLR9 1174 | GG | 53(16) | 29(32) | 17(22) | 35(43) | 22(27) | 14(17) |
| Â | GA | 147(44) | 47(53) | 47(60) | 38(46) | 33(41) | 40(48) |
| Â | AA | 136(41) | 12(14) | 14(18) | 9(11) | 26(32) | 29(35) |
MAL 180 | Ser/Ser | 254(73) | 89(100) | 75(95) | 82(91) | 53(68) | 73(88) |
| Â | Ser/Leu | 81(23) | 0 | 4(5) | 6(7)III | 25(32) | 10(12) |
| Â | Leu/Leu | 11(3) | 0 | 0 | 2(2) | 0 | 0 |