Malaria Journal

Table 3 TLR2, TLR4, and TLR9 haplotypes in various populations

From: Toll-like receptor polymorphisms in malaria-endemic populations

		PNG	Kenya		North America
Gene	Haplotype	lowlands	lowlands	highlands	African	Caucasian	Asian
TLR2^I
	DL	0.029	0.000	0.000	0.000	0.000	0.086
	DM	0.011	0.258	0.239	0.164	0.099	0.105
	DS	0.093	0.041	0.092	0.051	0.033	0.063
	WL	0.355	0.110	0.100	0.161	0.388	0.300
	WM	0.509	0.559	0.515	0.572	0.480	0.293
	WS	0.003	0.033	0.054	0.052	0.000	0.154
TLR4^II
	Asp-Thr	1^IV	0.924	0.943	0.869	0.905	0.952
	Gly-Ile	0	0.015	0.007	0.028	0.089	0.030
	Gly-Thr	0	0.061	0.050	0.102	0.000	0.012
	Asp-Ile	0	0.000	0.000	0.000	0.006	0.006
TLR9^III
	C C A	0.000	0.006	0.007	0.000	0.000	0.000
	C C G	0.000	0.075	0.099	0.092	0.000	0.011
	C T A	0.003	0.000	0.011	0.018	0.000	0.007
	C T G	0.368	0.205	0.136	0.244	0.353	0.343
	T C G	0.000	0.266	0.254	0.256	0.115	0.055
	T T A	0.625	0.396	0.455	0.324	0.526	0.584
	T T G	0.005	0.051	0.037	0.066	0.006	0.000

^IΔ22-GT_n haplotypes
D is deletion allele, W is wild type
S < 16 repeats, M 16–23 repeats, L > 23 repeats.
^IIFirst amino acid is 299, second amino acid is 399
^IIIFirst nucleotide is -1486, second is -1237, and third is 1174.
^IVGenotyped previously [50]

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ISSN: 1475-2875

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