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Table 3 Comparison of residues implicated in sulphate binding

From: Structural insights into chondroitin sulphate A binding Duffy-binding-like domains from Plasmodium falciparum: implications for intervention strategies against placental malaria

 

CSA-binding DBL domains

Non-binders

A4 3X

3D7 3X

2X

5ε

6ε

A4 4ε

3D7 1X

  

A4

3D7

A4

3D7

A4

3D7

  

Sulfate binding residues

K 1324*

R

-

-

-

-

-

-

H

-

G 1329*

G

-

-

K

-

-

-

-

-

R1467*

Q

A

E

E

E

K

E

K

N

K1504 #

K

E

K

E

E

A

A

A

K

Residues within 5Ã… of modelled CSA

K1327#

M

-

K

-

K

-

-

-

 

R1503#

R

D

N

S

S

H

E

K

D

K1507#

E

K

V

K

K

N

N

N

K

K1510#

K

K

K

E

E

N

N

N

E

  1. • [10, 11].
  2. • Conserved residues are in bold, acidic residues are in italics and underlined and other residues are bold and underlined.