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Table 1 Treatment outcome classification system using standardised criteria [7].

From: The effect of varying analytical methods on estimates of anti-malarial clinical efficacy

Outcome Category Outcome Code Outcome Definition Africa Thailand Total
Follow-up completed 0 ACPR 4385 4604 8989
  1 ETF with death 0 1 1
  2 ETF with severe malaria 5 0 5
  3 ETF with danger signs 39 0 39
  4 ETF with parasitological criteria 58 1 59
  5 ETF with clinical criteria 9 0 9
  6 ETF not otherwise specified 0 11 11
  7 LCF with death 0 0 0
  8 LCF with severe malaria 0 0 0
  9 LCF with danger signs 4 0 4
  10 LCF with fever 1033 654 1687
  11 LPF 1726 665 2391
  12 LPF/LCF indistinguishable 0 737 737
Follow-up interrupted 13 Adverse event requiring change in anti-malarial therapy 0 2 2
  14 Treatment protocol violation 4 138 142
  15 Death not due to malaria 0 3 3
  16 Lost to follow-up 175 955 1130
  17 Use of other anti-malarials outside of study protocol 48 6 54
  18 Withdrawal of consent prohibiting further follow-up 126 1 127
  19 Investigator initiated withdrawal from further follow-up 7 0 7
  20 Patient who does not complete follow-up for any other reason 0 12 12
  1. ACPR = adequate clinical and parasitological response; ETF = early treatment failure; LCF = late clinical failure; LPF = late parasitological failure