The effect of varying analytical methods on estimates of anti-malarial clinical efficacy

Malaria Journal

Table 1 Treatment outcome classification system using standardised criteria [7].

Outcome Category	Outcome Code	Outcome Definition	Africa	Thailand	Total
Follow-up completed	0	ACPR	4385	4604	8989
	1	ETF with death	0	1	1
	2	ETF with severe malaria	5	0	5
	3	ETF with danger signs	39	0	39
	4	ETF with parasitological criteria	58	1	59
	5	ETF with clinical criteria	9	0	9
	6	ETF not otherwise specified	0	11	11
	7	LCF with death	0	0	0
	8	LCF with severe malaria	0	0	0
	9	LCF with danger signs	4	0	4
	10	LCF with fever	1033	654	1687
	11	LPF	1726	665	2391
	12	LPF/LCF indistinguishable	0	737	737
Follow-up interrupted	13	Adverse event requiring change in anti-malarial therapy	0	2	2
	14	Treatment protocol violation	4	138	142
	15	Death not due to malaria	0	3	3
	16	Lost to follow-up	175	955	1130
	17	Use of other anti-malarials outside of study protocol	48	6	54
	18	Withdrawal of consent prohibiting further follow-up	126	1	127
	19	Investigator initiated withdrawal from further follow-up	7	0	7
	20	Patient who does not complete follow-up for any other reason	0	12	12

ACPR = adequate clinical and parasitological response; ETF = early treatment failure; LCF = late clinical failure; LPF = late parasitological failure

ISSN: 1475-2875