Table 2 Effect of concomitant medication (ketoconazole, mefloquine, quinine or lopinavir/ritonavir) on exposure to artemether, dihydroartemisinin (DHA) and lumefantrine in studies undertaken in healthy volunteers
Concomitant medication | N | Change in exposure to artemether (AUC) | Change in exposure to DHA (AUC) | Change in exposure to lumefantrine (AUC) | Change in exposure to concomitant medication (AUC)a |
|---|---|---|---|---|---|
Ketoconazole [8] | 16 | ↑ 2.4-fold | ↑ 1.7-fold | ↑ 1.7-fold | Not measured |
Mefloquine [21] | 42 | Unchanged | Unchanged | ↓ 32% | Unchanged |
Quinine [22] | 42 | ↓ 46% | ↓ 37% | Unchanged | Unchanged |
Lopinavir/ritonavir [24] | 13 | ↓ 35% | ↓ 45% | ↑ 2.4-fold | Unchanged |