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Figure 3 | Malaria Journal

Figure 3

From: Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

Figure 3

Vitamin E deficiency leads to P. berghei NK65 DNA damage. (A) Comet assay, indicating severe DNA damage, on the parasites recovered from α-TTP knockout or C57BL/6J mice. (B) Malarial parasites from α-TTP knockout and C57BL/6J mice stained with anti 8-OHdG (green), a biomarker of oxidative DNA damage. The DNA of the parasites was stained with propidium iodide (red) (n = 4). (C) C57BL/6J mice infected with parasites recovered from the α-TTP knockout (α-ttpΔ → B6) or C57BL/6J mice (B6 → B6). α-TTP knockout mice infected with parasites recovered from α-TTP knockout mice (α-ttpΔ → α-ttpΔ) or C57BL/6J mice (B6 → α-ttpΔ) (n = 6). *: p < 0.05 B6 → B6 vs α-ttpΔ → B6; **: p < 0.01 B6 → α-ttpΔ vs α-ttpΔ → α-ttpΔin panel C. In panel D *: p < 0.05 B6 → B6, α-ttpΔ → B6 vs B6 → α-ttpΔ, α-ttpΔ → α-ttpΔ.

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