Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum

Table 1 In vitro susceptibility of Plasmodium falciparum strains to atorvastatin alone (AVA), quinine alone (QN) and the combination of QN + AVA at concentrations of 0.1 μM, 0.5 μM and 1.0 μM.

Strains	IC₅₀ AVA alone	IC₅₀ QN alone	IC₅₀ QN + AVA 0.1 μM	IC₅₀ QN + AVA 0.5 μM	IC₅₀ QN + AVA 1.0 μM
IC₅₀ geometric mean	7.24 μM	359 nM	341 nM	321 nM	280 nM
IC₅₀ mean 95% CI	6.68-7.86	216-596	203-574	190-542	165-474
Average IC₅₀ diminution			5%	10%	22%
Average IC₅₀ diminution 95%CI			1%-8%	7%-14%	19%-25%
P-value (vs QN alone)			0.009	< 0.001	< 0.001

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