Table 3 Comparison of genetic divergence between apical membrane antigen-1 (AMA1) sequences P. falciparum infections occurring in children immunized with a bivalent AMA1 malaria vaccine or control vaccine, before and after immunization, and in comparison with the vaccine strains 3D7 and FVO
From: Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
| Â | Average number of nucleotide differences (k) | Average number of nucleotide substitutions per site (Dxy) | Number of net nucleotide substitution between population (Da) |
|---|---|---|---|
Comparison at baseline | Â | Â | Â |
   Malaria vaccine vs. control group | 20.805 | 0.0172 | 0.0003 |
Pre- vs. post-immunization | Â | Â | Â |
   Control group | 20.694 | 0.0173 | 0.0004 |
   Malaria vaccine group | 20.773 | 0.0173 | -0.0001 |
Comparison after immunization | Â | Â | Â |
   Malaria vaccine vs. control group | 20.739 | 0.0172 | -0.00002 |
Comparisons with vaccine strains | Â | Â | Â |
   At baseline |  |  |  |
Controls vs. 3D7 | 19.971 | 0.0193 | 0.0111 |
Control group vs. FVO | 19.775 | 0.0173 | 0.0091 |
Malaria vaccine group vs. 3D7 | 21.108 | 0.0166 | 0.0078 |
Malaria vaccine group vs. FVO | 21.394 | 0.0193 | 0.0104 |
   Post-immunization |  |  |  |
Controls vs. 3D7 | 20.743 | 0.0179 | 0.0111 |
Control vs. FVO | 20.768 | 0.0193 | 0.0107 |
Malaria vaccine group vs. 3D7 | 20.780 | 0.0176 | 0.009 |
Malaria vaccine group vs. FVO | 20.807 | 0.0192 | 0.0106 |