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Table 3 In vitro response of P. falciparum to anti-malarial drugs in the 1998, 2001, 2004/5, and 2008/9 surveys

From: Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009

Drug Year Sample EC50 (95% CI) 1 EC90 (95% CI) EC 99 (95% CI)
Chloroquine 1998 30 36.7 (27.6 - 48.7) 129 (85.5-194) 360 (196 - 659)
  2001 59 24.4 (19.6 - 30.2) 72.5 (51.2-103) 177 (103 - 302)
  2004/5 34 37.7 (25.8-55.0) 293 (139-617) 1,562 (462 -5,279)
  2008/9 81 67.8 (56.1 - 82.0) 253 (202-358) 735 (535 - 1,272)
Mefloquine 1998 35 83.3 (66.5 - 104) 201 (149-270) 412 (272-622)
  2001 59 42.2 (35.5-50.1) 101 (78.9-129) 205 (143 - 293)
  2004/5 25 60 (42.2 - 85.6) 250 (145-430) 796 (347 - 1,824)
Quinine 1998 31 245 (176-320) 820 (494-1,361) 2,197 (1,018-4,746)
  2001 58 96.3
(78- 119)
277
(199-387)
658
(394-1,098)
Artemisinin2 1998 34 30.5 (20.4- 45.5) 201 (111-364) 937 (387 - 2,269)
  2001 58 26.9 (17.2-42.2) 426 (198-914) 4041 (1213-13461)
  2004/5 34 13.7 (8.5 - 22.0) 126 (58.6 - 272) 772 (235-2,537)
  2008/9 46 17.4 (12.0 - 25.3) 92.0 (54.9 - 154) 358 (170 -756)
Piperaquine 2008/9 81 21.1 (16.5-27.1) 62 (91.8-136) 304 (167-554)
DHA 2008/9 81 1.7 (1.4 - 2.2) 14.1 (9-22) 78 (37-163)
  1. 1. Values are mean effective concentrations (EC) for P. falciparum isolates (number = n) calculated for 50%, 90%, 99% schizont maturation inhibition. Units: nmol/L blood medium mix and 95% confidence intervals.
  2. 2. Fresh microtest plates prepared at NIMPE were used in the artemisinin experiments. These were replenished in the field every three months in 1998 and 2001, and every 2 weeks in 2004/5 and 2008/9