Table 3 In vitro response of P. falciparum to anti-malarial drugs in the 1998, 2001, 2004/5, and 2008/9 surveys
Drug | Year | Sample | EC50 (95% CI) 1 | EC90 (95% CI) | EC 99 (95% CI) |
|---|---|---|---|---|---|
Chloroquine | 1998 | 30 | 36.7 (27.6 - 48.7) | 129 (85.5-194) | 360 (196 - 659) |
| Â | 2001 | 59 | 24.4 (19.6 - 30.2) | 72.5 (51.2-103) | 177 (103 - 302) |
| Â | 2004/5 | 34 | 37.7 (25.8-55.0) | 293 (139-617) | 1,562 (462 -5,279) |
| Â | 2008/9 | 81 | 67.8 (56.1 - 82.0) | 253 (202-358) | 735 (535 - 1,272) |
Mefloquine | 1998 | 35 | 83.3 (66.5 - 104) | 201 (149-270) | 412 (272-622) |
| Â | 2001 | 59 | 42.2 (35.5-50.1) | 101 (78.9-129) | 205 (143 - 293) |
| Â | 2004/5 | 25 | 60 (42.2 - 85.6) | 250 (145-430) | 796 (347 - 1,824) |
Quinine | 1998 | 31 | 245 (176-320) | 820 (494-1,361) | 2,197 (1,018-4,746) |
| Â | 2001 | 58 | 96.3 (78- 119) | 277 (199-387) | 658 (394-1,098) |
Artemisinin2 | 1998 | 34 | 30.5 (20.4- 45.5) | 201 (111-364) | 937 (387 - 2,269) |
| Â | 2001 | 58 | 26.9 (17.2-42.2) | 426 (198-914) | 4041 (1213-13461) |
| Â | 2004/5 | 34 | 13.7 (8.5 - 22.0) | 126 (58.6 - 272) | 772 (235-2,537) |
| Â | 2008/9 | 46 | 17.4 (12.0 - 25.3) | 92.0 (54.9 - 154) | 358 (170 -756) |
Piperaquine | 2008/9 | 81 | 21.1 (16.5-27.1) | 62 (91.8-136) | 304 (167-554) |
DHA | 2008/9 | 81 | 1.7 (1.4 - 2.2) | 14.1 (9-22) | 78 (37-163) |