Study Location
|
Characteristic
|
Gela
|
CEb
|
P valuec
|
---|
Kanungu
(n = 90)
|
Probability two randomly selected alleles will match by chanced
|
0.066
|
0.025
|
<0.001
|
|
MOI Day 0e, mean (SD)
|
2.73 (1.53)
|
3.82 (2.58)
|
<0.001
|
|
MOI Day Ff, mean (SD)
|
1.23 (1.14)
|
2.02 (1.82)
|
<0.001
|
|
Pmatch g, median (IQR)
|
0.20 (0.11 - 0.36)
|
0.16 (0.06 - 0.26)
|
0.001
|
Apac
(n = 209)
|
Probability two randomly selected alleles will match
|
0.061
|
0.028
|
<0.001
|
|
MOI Day 0, mean (SD)
|
3.65 (1.80)
|
5.06 (3.42)
|
<0.001
|
|
MOI Day F, mean (SD)
|
2.42 (1.59)
|
3.26 (2.62)
|
<0.001
|
|
Pmatch, median (IQR)
|
0.41 (0.23 - 0.59)
|
0.27 (0.12 - 0.50)
|
<0.001
|
- a Gel, Agarose gel electrophoresis
- b CE, Capillary electrophoresis
- c P values testing the hypothesis Gel is different than CE using a bootstrap test for the probability two alleles will match by chance, and the Wilcoxon Rank Sum test for other characteristics
- d Calculated using the empiric distribution of Day 0 alleles and criteria for a match based on the electrophoresis method
- e Multiplicity of infection (number of alleles detected) on Day 0 (day of anti-malarial treatment)
- f Multiplicity of infection on Day F (day of failure, i.e. recurrent parasitaemia)
- g Probability of a genotyping match occurring by chance for each sample, calculated using the actual alleles present on Day 0 and the multiplicity of infection on Day F (MOI-F). Ten thousand random combinations of MOI-F alleles were chosen for Day F using the empiric frequency distribution, and Pmatch is the proportion of these combinations that had at least one allele match with the Day 0 alleles.