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Table 1 The nucleotide and amino acid substitutions at (a) dhfr and (b) dhps genes screened for by PCR-SSOP

From: Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine

dhfr      
Codon 50 51 59 108 164
Wild type Cys (C) TGT Asn (N) AAT Cys (C) TGT Ser (S) AGC Ile (I) ATA
   AAC    
Mutant Arg (R) Ile (I) Arg (R) Asn (N) Leu (L)
  CGT ATT CGT AAC TTA
     Thr (T)  
     ACC  
dhps      
Codon 436 437 540 581 613
Wild type Ser (S) Ala (A) Lys (K) Ala (A) Ala (A)
  TCT GCT AAA GCG GCC
Mutant Phe (F) Gly (G) Glu (E) Gly (G) Ser (S)
  TTT GGT GAA GGG TCC
  Ala (A)     Thr (T)
  GCT     ACC
  Cys (C)     
  TGT