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Table 1 The nucleotide and amino acid substitutions at (a) dhfr and (b) dhps genes screened for by PCR-SSOP

From: Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine

dhfr

     

Codon

50

51

59

108

164

Wild type

Cys (C) TGT

Asn (N) AAT

Cys (C) TGT

Ser (S) AGC

Ile (I) ATA

  

AAC

   

Mutant

Arg (R)

Ile (I)

Arg (R)

Asn (N)

Leu (L)

 

CGT

ATT

CGT

AAC

TTA

    

Thr (T)

 
    

ACC

 

dhps

     

Codon

436

437

540

581

613

Wild type

Ser (S)

Ala (A)

Lys (K)

Ala (A)

Ala (A)

 

TCT

GCT

AAA

GCG

GCC

Mutant

Phe (F)

Gly (G)

Glu (E)

Gly (G)

Ser (S)

 

TTT

GGT

GAA

GGG

TCC

 

Ala (A)

   

Thr (T)

 

GCT

   

ACC

 

Cys (C)

    
 

TGT