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Figure 4 | Malaria Journal

Figure 4

From: Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

Figure 4

Individual compounds EA and punicalagin inhibit Hz-induced MMP-9 promoter activity. Ellagitannins were able to affect MMP-9 transcription since EA inhibited Hz-induced promoter activity by 38% and 50% at 1 and 10 μM, respectively, while the inhibitory effect of punicalagin was only statistically significant at 10 μM (-65%). Parthenolide (10 μM) was used as reference inhibitor of the MMP-9 (~80% inhibition) promoter activity. Data are expressed as mean ± S.D. of triplicate samples. All experiments were reproduced at least three times and, where indicated, representative experiments are shown. Statistical analyses were performed with GraphPad Prism 5 software, using 1-way ANOVA test followed by Bonferroni's post hoc test. The significance was indicated as ** p < 0.01.

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Malaria Journal

ISSN: 1475-2875

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