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Table 1 GM/KM phenotypes in relation to IgG subclass-specific antibodies to PvMSP1-19 in subjects exposed to malaria

From: Immunoglobulin GM 3 23 5,13,14 phenotype is strongly associated with IgG1 antibody responses to Plasmodium vivax vaccine candidate antigens PvMSP1-19 and PvAMA-1

Phenotypes
(Number of subjects)
Antibody levels (Reactivity Index) (Median, Interquartile range)
  IgG1 IgG2 IgG3 IgG4
GM 1,2,17 21 (9) 0.63(0.01-2.67) 0.05(0.01-0.21) 0.35(0.01-1.53) 0.01(0.01-0.18)
GM 1,17 5,13,14,21 (15) 0.87(0.55-1.97) 0.29(0.01-0.82) 1.66(0.01-6.31) 0.44(0.01-0.58)
GM 1,2,3,17 23 5,13,14,21 (13) 2.65(0.32-4.26) 0.33(0.01-0.46) 3.17(0.44-5.25) 0.11(0.01-0.48)
GM 1,3,17 23 5,13,14,21 (28) 0.76(0.01-3.57) 0.11(0.00-0.40) d0.15(0.01-2.74) 0.09(0.01-0.52)
GM 1,3,17 23 5,6,13,14 (10) 1.88(1.49-3.37) 0.16(0.02-0.50) 0.47(0.02-2.40) 0.09(0.01-0.23)
GM 1,3,17 5,13,14,21 (18) 2.55(0.21-4.07) 0.31(0.06-1.54) 1.68(0.01-4.46) f0.30(0.01-0.99)
GM 3 23 5,13,14 (20) b3.60(1.89-4.71) 0.16(0.03-1.25) 2.49(0.25-5.81) 0.08(0.01-0.58)
aOther GM (71) 2.27(0.25-3.31) 0.28(0.01-0.67) 1.44(0.08-5.06) 0.17(0.01-0.43)
KM 1 (9) 1.18(0.01-2.44) c0.02(0.01-0.16) e0.01(0.01-2.35) 0.01(0.01-0.46)
KM 1,3 (68) 1.75(0.53-3.48) 0.18(0.00-0.64) 1.44(0.13-5.81) 0.19(0.01-0.56)
KM 3 (107) 2.32(0.18-3.86) 0.22(0.01-0.68) 1.53(0.06-3.83) 0.13(0.01-0.40)
  1. aOther GM [(GM 1,17 21 (n = 5), GM 1,17 5,6,14,21 (n = 5), GM 3 5,13,14 (n = 4), GM 1,17 13,21 (n = 5), GM 1,17 6,14,21 (n = 1), GM 1,2,17 13,21 (n = 4), GM 1,2,17 13,14,21 (n = 2), GM 1,3,17 13,14,21 (n = 1), GM 1,17 23 5,13,14,21 (n = 1), GM 1,17 5,6,13,14 (n = 4), GM 1,17 5,6,13,14,21 (n = 4), GM 1,17 5,14,21 (n = 2), GM 1,2,17 5,6,13,14,21 (n = 1), GM 1,2,17 5,6,14,21 (n = 4), GM 1,2,17 5,6,21 (n = 2), GM 1,2,3,17 5,6,13,14,21 (n = 1), GM 1,3,17 23 5,6,13,14,21 (n = 5), GM 1,3,17 5,13,14 (n = 4), GM 1,3,17 5,6,13,14 (n = 5), GM 1,3,17 5,6,13,14,21 (n = 3), GM 1,2,17 5,13,14,21 (n = 3), GM 1,2,3,17 5,13,14,21 (n = 5)]
  2. bsignificantly higher (P = 0.004), csignificantly lower (P = 0.031), dsignificantly lower (P = 0.051),
  3. esignificantly lower (P = 0.027), fsignificantly higher (P = 0.002), (obtained by Wilcoxon-Mann-Whitney test) compared with the rest of the GM phenotypes.