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Figure 4 | Malaria Journal

Figure 4

From: Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

Figure 4

ELISpot activity against AMA1-14e after CD4+ or CD8+ T cell depletion. PBMC from v001 and v005 were tested in IFN-γ ELISpot assays after CD4+ or CD8+ T cell depletion (top panel), and in ICS assay for total % CD4+ or CD8+ T cell IFN-γ (lower panel), with Ap1-12 (all 153 15-mer peptides), AMA1-14e, and AMA1 recombinant protein (AMA rp). ELISpot depletion and ICS assays show that AMA1-14e and Ap1-12 are both strongly recognized by CD8+ T cells. However, recombinant AMA1 protein is preferentially recognized by CD4+ T cells.

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