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Table 2 Descriptive statistics of diagnostic accurary of neopterin, procalcitonin as compared with lactate for the diagnosis of severe falciparum malaria on admission.

From: Neopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria

  Neopterin
95% Confidence Interval
Procalcitonin
95% Confidence Interval
Lactate
95% Confidence Interval
Optimal cut-off value 10 ng/ml 0.9 ng/ml 1.8 mmol/l
Youden's index 0.60   0.53   0.58  
Sensitivity 0.93 0.64-1.00 1.00 0.70-1.00 0.92 0.60-1.00
Specificity 0.67 0.54-0.78 0.53 0.40-0.66 0.66 0.51-0.78
Positive predictive value 0.38 0.23-0.56 0.30 0.17-0.47 0.39 0.22-0.59
Negative predictive value 0.98 0.86-1.00 1.00 0.87-1.00 0.97 0.83-1.00
  1. The Youden's index was used to choose an appropriate cut-off value.