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Table 3 Five TNF alleles polymorphism (TNF P-1, TNF P-2, TNF P-3, TNF P-4, TNF P-5) based on three SNPs of biallelic polymorphism sites (-857, -863, -1031) in patients with severe (SM), uncomplicated falciparum (UM) and vivax malaria (VM) cases when data were combined for the three ethnic groups

From: Study on association between genetic polymorphisms of haem oxygenase-1, tumour necrosis factor, cadmium exposure and malaria pathogenicity and severity

TNF type

Polymorphic sites of the promoter region of TNF-α gene

SM

UM

VM

 

-857

-863

-1031

(%)

(%)

(%)

TNFP-1

C

C

T

49.2

57.2

57.7

TNFP-2

T

C

T

6.3

4.3

3.5

TNFP-3

C

A

C

39.7

34.5

34.5

TNFP-4

C

C

C

3.2

3.0

3.5

TNFP-5

C

A

T

1.6

1.0

0.7