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Table 2 Median values of antibody responses to varO-IE crude extract and varO recombinant domains, for healthy adults (HA) and children (AP, UM and SM, in 2006)

From: The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children

Antigens

Median values (AU) a

HA (n = 30)

AP (n = 52)

UM (n = 37)

SM (n = 65)

varO-IE crude extract IgG

95.6 (90.2-97.1)

86.6 (78.4-93.5) b

86.4 (69.7-90.1) c

72.2 (61.1-84.2)d, f, g

NTS-DBL1α 1 :

IgG

93.7 (88.9-99.5)

92.3 (74.0-105.9)

65.7 (61.9-79.9) c, e

64.4 (52.5-83.8) d, f

IgG1

nd

93.3 (82.2-99.3)

34.7 (21.6-50.1) e

37.0 (29.9-60.3) f

IgG3

nd

64.3 (42.9-80.2)

35.7 (27.4-46.8) e

46.3 (36.3-64.6) f, g

CIDRγ:

IgG

88.9 (63.6-103.4)

64.2 (49.7-100.9)

74.4 (53.3-107.3)

47.2 (39.3-52.4) d, f

IgG1

nd

83.5 (65.9-97.4)

75.1 (55.4-95.7)

65.1 (51.2-68.9) f

IgG3

nd

65.7 (51.4-81.0)

94.0 (64.2-107.0)

63.9 (45.7-70.0)

DL2βC2:

IgG

73.2 (59.4-90.4)

68.7 (47.0-82.2)

54.8 (43.4-70.8)

47.8 (37.6-68.3) d

IgG1

nd

93.3 (78.8-101.0)

82.8 (75.6-93.0)

81.9 (76.9-93.2)

IgG3

nd

64.2 (47.6-77.0)

48.2 (44.0-53.8)

69.8 (50.7-88.6)

  1. nd: not done
  2. a Median values (25th-75th percentiles), including responders only, and expressed in arbitrary units (AU).
  3. Significant differences (Mann-Whitney U-test, P < 0.05) between median values of HA and AP responders (b), HA and UM responders (c), HA and SM responders (d), AP and UM responders (e), AP and SM responders (f), and UM and SM responders (g).