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Table 3 Per Protocol analysis of pregnancy outcomes for women randomized in the trial using Poisson regression analysis with robust error estimation (crude and adjusted incident rate ratios)

From: Intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine during pregnancy in Burkina Faso: effect of adding a third dose to the standard two-dose regimen on low birth weight, anaemia and pregnancy outcomes

  Prevalence (Proportion) of women with characteristics Crude IRR (95% CI) Adjusted IRR* (95% CI)
Characteristics 2-dose SP 3-dose SP
Overall     
   LBW 11.9 (28/235) 9.6 (13/136) 0.80 (0.42 - 1.49) 0.84 (0.45 - 1.54)
   Anaemia 46.1 (119/258) 50.7 (75/148) 1.09 (0.89 - 1.35) 1.12 (0.91 - 1.38)
   Severe anaemia 2.3 (6/258) 1.4 (2/148) 0.58 (0.12 - 2.84) 0.63 (0.12 - 3.46)
   Premature delivery (%) 11.3 (29/257) 9.5 (14/148) 0.83 (0.46 - 1.53) 0.77 (0.43 - 1.35)
   Spontaneous abortion (%) 1.2 (3/257) 2.0 (3/148) 1.73 (0.35 - 8.51) 1.56 (0.34 - 7.10)
   Stillbirth 1.2 (3/257) 2.7 (4/148) 2.31 (0.5 - 10.22) 2.32 (0.47 - 11.36)
   Neonatal death 1.3 (2/136) 1.5 (2/136) 1.15 (0.19 - 6.82) 1.29 (0.21 - 7.99)
Gravidae 1     
   LBW 19.2 (9/47) 13.6 (3/22) 0.71 (0.21 - 2.39) 0.78 (0.22 - 2.72)
   Anaemia 63.5 (33/52) 58.3 (14/24) 0.92 (0.62 - 1.36) 1.00 (0.68 - 1.49)
   Severe anaemia 3.9 (2/52) 0 - -
   Premature delivery (%) 17.3 (9/52) 12.5 (3/24) 0.72 (0.21 - 2.45) 0.56 (0.15 - 2.09)
   Spontaneous abortion (%) 3.9 (2/52) 4.2 (1/24) 1.08 (0.10 - 11.52) 0.31 (0.08 - 1.25)
   Stillbirth 1.9 (1/52) 0 - -
   Neonatal death 4.3 (2/47) 0 - -
Gravidae 2-3     
   LBW 15.4 (12/78) 11.5 (6/52) 0.75 (0.29 -1.87) 0.81 (0.32 - 2.01)
   Anaemia 41.7 (35/84) 43.9 (25/57) 1.05 (0.71 - 1.55) 1.10 (0.73 - 1.66)
   Severe anaemia 2.4 (2/84) 1.8 (1/57) 0.89 (0.06 - 8.00) 0.92 (0.10 - 8.77)
   Premature delivery (%) 15.5 (13/84) 12.3 (7/57) 0.79 (0.34 - 1.87) 0.77 (0.35 - 1.68)
   Spontaneous abortion (%) 0 1.8 (1/57) - -
   Stillbirth 0 5.3 (3/57) - -
   Neonatal death 0 0.8 (1/130) - -
Gravidae ≥4     
   LBW 6.4 (7/110) 6.5 (4/62) 1.01 (0.31 - 3.34) 1.09 (0.32 - 3.68)
   Anaemia 41.8 (51/122) 53.7 (36/67) 1.28 (0.95 - 1.75) 1.26 (0.92 - 1.71)
   Severe anaemia 1.6 (2/122) 1.5 (1/67) 0.91 (0.08 - 9.91) -
   Premature delivery (%) 5.8 (7/121) 5.9 (4/67) 0.72 (0.21 - 2.45) -
   Spontaneous abortion (%) 0.8 (1/121) 1.5 (1/67) - -
   Stillbirth 1.6 (2/121) 1.5 (1/67) 0.90 (0.08 - 9.83) 0.77 (0.04 - 15.87)
   Neonatal death 0.9 (1/110) 1.6 (1/62) 1.77 (0.11 - 2.80) -
  1. *Adjusted for age category, BMI, malaria infection, malaria season at delivery, supplementation and parity category (the later in the overall analysis only)