Figure 2

Platelet derived MPs (PMPs) correlate with fever and length of symptoms of acute malaria and may be impacted by cumulative clinical malarial episodes. P. vivax malaria patients were categorized according to their body temperature (°C) (A); prolonged symptoms (B); cumulative malarial episodes (median 5, range 0 - 60) (C); and the time since last malarial episode (D). Boxes represent median and interquartile interval, whiskers represent the 10 and 90 percentiles. Data were transformed into neperian logarithm before applied to linear regression analysis. Positive linear trends were observed between the frequency of PMPs in plasma and presence of fever (above 37.5°C) at the time of blood collection (β = 0.06, p < 0.0001), length of malaria symptoms, estimated here by number of days with acute illness (β = 0.36, p < 0.0001), and previous clinical malaria episodes (β = 0.07, p < 0.003).