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Figure 2 | Malaria Journal

Figure 2

From: Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter

Figure 2

Adenosine transport in Plasmodium falciparum -infected and uninfected human erythrocytes in the presence or absence of NBMPR. Uptake of 0.5 μM [3H]-adenosine in Percoll-enriched infected (closed symbols, dashed lines) and uninfected (open symbols, solid lines) erythrocytes without inhibitor (squares), in the presence of inhibitor (circles) or 1 mM unlabelled adenosine (triangles). A, inhibitor is 0.1 μM NBMPR. Uptake in both infected and uninfected RBC was fully inhibited by either the presence of 1 mM adenosine or by 0.1 μM NBMPR. B, inhibitor is 100 μM furosemide. Adenosine uptake was not significantly reduced by 100 μM furosemide, either in infected or uninfected RBC. Uptake was expressed as pmol(107 cells)-1; experiments shown are representative of four independent experiments and conducted in triplicate; bars are SEM.

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Malaria Journal

ISSN: 1475-2875

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