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Table 1 Effect of immunization protocols with Plasmodium yoelii attenuated sporozoites on development of protective immunity

From: Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity

Route of Immunization Exp't 1 Exp't 2 Exp't 3 Total
Non-Immunized Controls 6/6 (0%)a
[PP = 3.0]b
6/6 (0%)
[PP = 3.3]
6/6 (0%)
[PP = 3.3]
18/18 (0%)
[PP = 3.3]
IVc-Immunized 0/6 (100%) 0/6 (100%) 1/6 (83%)
[PP = 6.0]
1/18 (94%)
[PP = 6.0]
IDd-Immunized 3/6 (50%)
[PP = 5.0]
1/6 (83%)
[PP = 9.0]
0/6 (100%) 4/18 (78%)
[PP = 6.0]
ID-Immunized
+ Imiquimod
1/6 (83%)
[PP = 5.0]
1/6 (83%)
[PP = 4.0]
4/6 (33%)
[PP = 4.2]
6/18 (67%)
[PP = 4.3]
ID-Immunized
+ Tape Stripping
1/6 (83%)
[PP = 4 0]
0/6 (100%) 0/6 (100%) 1/18 (94%)
[PP = 4.0]
  1. a Results of challenge by mosquito injection of sporozoites. # of mice with blood infection/# challenged; (% protected in parentheses)
  2. b [Mean prepatent period in days for positive mice]
  3. c IV = intravenous
  4. d ID = intradermal