Figure 3
From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
Structures and key biological data for diamine quinoline methanols. The P. falciparum IC90 and RAW macrophage LC50 data for mefloquine are presented as the mean +/- standard deviation. The LC50 values are against the macrophage cell line. Papp/recovery refers to the apparent permeability in the apical direction across MDR1-transfected MDCK cell monolayers (units in 10-6 cm/s) and the % recovery for each compound at the end of the experiment.