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Table 1 Phase-II enzyme activity, glutathione and TBARS in the liver of P.berghei-infected mice

From: Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models

Parameters GST UGT GSH TBARS
Sub-cellular fraction m c m c -
DBA-2 Infected
(N)
80.4 ± 4.5
(8)
700 ± 100
(8)
8.4 ± 3.2
(8)
86.0 ± 8.0
(7)
13.5 ± 3.9
(5)
  Control
(N)
91.0 ± 5.4
(8)
800 ± 100
(8)
9.0 ± 3.0
(8)
76.9 ± 9.0
(7)
39.0 ± 5.5*
(5)
C57BL/6 Infected
(N)
85.6 ± 6.1
(8)
1 400 ± 100
(6)
7.4 ± 3.7
(9)
35.0 ± 9.8
(6)
19.5 ± 2.7
(5)
  Control
(N)
95.9 ± 2.7
(8)
1 500 ± 100
(8)
5.5 ± 3.0
(9)
16.9 ± 8.6*
(8)
23.6 ± 12.3
(5)
  1. Data are mean ± S.E.M. m: microsomal fraction; c: cytosolic fraction; (N): number of animals. Values different from those for non-infected controls (Student's t test, P < 0.05) are indicated by an asterisk (*). Enzyme activities are expressed as nmol/mg ptn/min (mGST and UGT) and μmol/mg ptn/min (cGST). GSH as nmol/mg ptn; TBARS as nmol MDA/g wet tissue.