Skip to main content

Table 4 Assessment of recovery after treatment with intramuscular artesunate or artemether.

From: Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria

Parameters

ARTS

n = 186

ARTM

n = 184

P value*

hours

Time to parasite clearance

   

Decrease to 50% of admission value

  

0.007

Median (Range)

8 (4-42)

8 (2-60)

 

Decrease to 90% of admission value

  

0.004

Median (Range)

16 (4-102)

24 (2-152)

 

Total clearance

  

0.97

Median (Range)

72 (7-330)

72 (2-204)

 

Resolution of fever

   

Time first temperature < 37.5°C

  

0.99

Median (Range)

30 (0-768)

20 (0-648)

 

Time of fever clearance

  

0.27

Median (Range)

108 (0-888)

108 (0-1088)

 

Time to recovery from coma

   

Time to Glasgow Coma score of 8†

  

0.55

Median (Range)

48 (4-2136)

54 (2-2232)

 

Time to Glasgow Coma score of 11‡

  

0.44

Median (Range)

42 (4-2136)

42 (2-2232)

 

Time to Glasgow Coma score of 15¶

  

0.11

Median (Range)

60 (4-2136)

72 (2-2232)

 

Time to physical recovery

   

Time before patient able to drink

   

Median (Range)

30 (0-2136)

42 (0-2232)

0.2

Time before patient able to eat

   

Median (Range)

42 (0-2136)

46 (0-2232)

0.18

Time before patient able to sit

   

Median (Range)

78 (0-2136)

90 (0-2232)

0.32

Time before patient able to stand

   

Median (Range)

96 (0-2136)

114 (0-2232)

0.66

Time before patient able to walk

   

Median (Range)

102(0-2136)

120 (0-2232)

0.64

Time before patient able to leave hospital

   

Median (Range)

264(7-2136)

288 (2-2232)

0.68

  1. * Log-rank test
  2. † Only patients who decreased in Glasgow Coma score below 8 were included (130 pts, 58 in ATS group and 72 in ATM group)
  3. ‡ Only patients who decreased in Glasgow Coma score below 11 were included (204 pts, 93 in ATS group and 111 in ATM group)
  4. ¶Only patients who decreased in Glasgow Coma score below 15 were included (274 pts, 134 in ATS group and 140 in ATM group)