Skip to main content


You are viewing the new article page. Let us know what you think. Return to old version

Invited speaker presentation | Open | Published:

A common protein export pathway in malaria parasites

Protozoan parasites that cause malaria export hundreds of proteins into their host red blood cell cytosol, and some even beyond that to the extracellular environment. These proteins have a wide range of functions that are crucial to parasite virulence and/or parasite survival in the human host. It has been thought for some time that a common link to all these proteins is the mechanism by which they are exported. Recently, we have revealed much of how this export occurs, including the discovery of a novel translocon through which exported proteins must pass. As a common portal for many essential proteins this translocon becomes a strongly validated drug target.

Author information

Correspondence to Brendan Crabb.

Rights and permissions

Reprints and Permissions

About this article


  • Malaria
  • Malaria Parasite
  • Drug Target
  • Human Host
  • Protozoan Parasite


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.