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  • Invited speaker presentation
  • Open Access

A common protein export pathway in malaria parasites

  • 1,
  • 1,
  • 1,
  • 2,
  • 3,
  • 3,
  • 2 and
  • 1
Malaria Journal20109 (Suppl 2) :I3

https://doi.org/10.1186/1475-2875-9-S2-I3

  • Published:

Keywords

  • Malaria
  • Malaria Parasite
  • Drug Target
  • Human Host
  • Protozoan Parasite

Protozoan parasites that cause malaria export hundreds of proteins into their host red blood cell cytosol, and some even beyond that to the extracellular environment. These proteins have a wide range of functions that are crucial to parasite virulence and/or parasite survival in the human host. It has been thought for some time that a common link to all these proteins is the mechanism by which they are exported. Recently, we have revealed much of how this export occurs, including the discovery of a novel translocon through which exported proteins must pass. As a common portal for many essential proteins this translocon becomes a strongly validated drug target.

Authors’ Affiliations

(1)
Burnet Institute, Melbourne, 3004, Australia
(2)
School of Medicine, Deakin University Waurn Ponds campus, Geelong, 3217, Australia
(3)
Walter & Eliza Hall Institute, Parkville, 3052, Australia

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