Volume 9 Supplement 2

Parasite to Prevention: Advances in the understanding of malaria

Open Access

Impact of protective haemoglobins C and S on P. falciparum malaria transmission in endemic area

  • Louis C Gouagna1, 2,
  • Germana Bancone3,
  • Frank Yao4,
  • Carlo Costantini5,
  • Jean-Bosco Ouedraogo4 and
  • David Modiano3
Malaria Journal20109(Suppl 2):O17

https://doi.org/10.1186/1475-2875-9-S2-O17

Published: 20 October 2010

Human genetic factors play a key role in determining the resistance/ susceptibility to infectious diseases. It is unknown whether genetic makeup may also influence host efficiency to transmit pathogens. With regard to malaria, a major selective force in recent human evolution, protective erythrocyte variants have been describe, but little is known as to their possible impact on the transmission of the parasite from the human host to the Anopheles vector.

Here, we performed genetic, parasitological and entomological investigations involving a total of 3799 human subjects carrying the HbAA, HbAS, HbAC and HbCC β-globin genotypes in order to determine whether variation in host infectivity to the Anopheles vector can be accounted for by host genetic variation. Although no differences were observed in asexual parasite rates and densities among β-globin genotypes, the HbCC genotype was characterized by higher gametocyte rates than the rest of the studied population.

Furthermore, serial infection experiments with blood from CC, AC, AS, and AA donors showed that the protective haemoglobins C (HbC, β6Glu®Lys) and S (β6Glu®Val) are associated with a twofold in vivo (OR 2.17; 95% CI 1.57-3.01; P <0.001) and a fourfold ex vivo (OR 4.12; 95% CI 1.90-9.29; P <0.001) increase of parasite transmission from the human host to the Anopheles vector.

These findings represent the first demonstration that human genetic variation may also influence the transmission dynamics of an infectious disease. Interestingly, together with previous evidence on the protection against malaria conferred by HbC and HbS, the assembly of the collected parasitological and entomological information suggests that single β globin mutations may confer both a higher resistance to the disease for the host and higher transmissibility for the parasite.

Authors’ Affiliations

(1)
Institut de Recherche pour le Développement(IRD), Unité de Recherche 16
(2)
Centre de Recherche et de Veille sur les maladies Emergentes dans l'Océan Indien (CRVOI)
(3)
Department of Public Health Sciences, University of Rome 'La Sapienza'
(4)
Institut de Récherche en Sciences de la Santé (IRSS), Direction Régionale de Bobo-Dioulasso
(5)
IRD, Unité de Recherche 016, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale

References

  1. Gouagna LC, Bancone G, Yao F, Yameogo B, Dabiré KR, Costantini C, Simporé J, Ouedraogo JB, Modiano D: Genetic variation in human HBB is associated with Plasmodium falciparum transmission. Nat Genet. 2010, 42: 328-331. 10.1038/ng.554.View ArticlePubMedGoogle Scholar

Copyright

© Gouagna et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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