Table 1 Proportion of patients with suspected adverse drug reactions (SADRs) to various Artemisinin-based combination therapies (ACT) in Lagos (2008).
SADRs | Artemisinin Monotherapy (number of reports=410) | Artesunate-Mefloquine (number of reports=521) | Artesunate-Amodiaquine (number of reports=961) | Artemeter-Lumefantrine (number of reports=401) | Dihydro artemisinin/SP (number of reports=642) |
|---|---|---|---|---|---|
Anorexia | 19 | 25 | 52 | 14 | 33 |
Tightening of chest | 7 | 17 | 26 | 13 | 9 |
Rashes | 10 | 21 | 28 | 20 | 55 |
Pruritis | 6 | 22 | 39 | 16 | 28 |
Dizziness | 33 | 48 | 93 | 32 | 39 |
Restlessness | 35 | 35 | 79 | 24 | 29 |
Headache | 39 | 31 | 51 | 25 | 37 |
General body pain | 19 | 24 | 43 | 16 | 18 |
Weakness/fatigue | 43 | 47 | 102 | 32 | 46 |
Vomiting | 5 | 11 | 15 | 5 | 20 |
Abdominal discomfort | 37 | 25 | 52 | 30 | 32 |
Insomnia | 17 | 21 | 46 | 13 | 29 |
Swollen/blistered lips | 9 | 6 | 10 | 11 | 46 |
Hallucination | 3 | 17 | 16 | 9 | 14 |