| Week | CQ control | CQ-CPS iv | CQ-CPS 100 μg sc | CQ-CPS sc |
---|---|---|---|---|---|
n = 4 | n = 8 | n = 8 | n = 8 | ||
Immunization/drug treatment (prime; boost 1; boost 2) | 0; 1; 2 | - / CQ-DW | 3 × 103 SPZ iv / CQ-DW | 3 × 104 SPZ + 100 μg his and 5IU hep sc / CQ-DW | 3 × 104 SPZ sc / CQ-DW |
Challenge | 8 | 104 SPZ iv | 104 SPZ iv | 104 SPZ iv | 104 SPZ iv |
Animals protected | Â | 0/4 | 8/8 | 2/8 | 0/6* |
Animals surviving by day 14 post-challenge | Â | 1/4 | 8/8 | 8/8 | 6/6 |