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Table 3 Comparison of IC 50 values determined using the Pf LDH assay in 2006 in the same population and the Sybr Green assays in 2012

From: Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

 

2005-2007

2011-2013

P -value

Drug

n

IC 50

n

IC 50

 

Chloroquine

63

167 (141–197)

48

87 (71–106)

<0.001

Piperaquine

57

11.7 (10.2-13.4)

47

21.1 (17–26)

<0.001

Naphthoquine

41

7.0 (5.5-8.8)

44

4.2 (3.1-5.8)

0.015

Lumefantrine

25

2.4 (1.8-3.1)

47

1.5 (1.1-2.1)

0.075

Dihydroartemisinin

30

2.1 (1.5-2.9)

50

5.2 (4.2-6.5)

<0.001

  1. Data are geometric mean and (95% CI) and P-values are two-tailed from Student’s t-test.
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Malaria Journal

ISSN: 1475-2875

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