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Table 3 Comparison of IC 50 values determined using the Pf LDH assay in 2006 in the same population and the Sybr Green assays in 2012

From: Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

  2005-2007 2011-2013 P -value
Drug n IC 50 n IC 50  
Chloroquine 63 167 (141–197) 48 87 (71–106) <0.001
Piperaquine 57 11.7 (10.2-13.4) 47 21.1 (17–26) <0.001
Naphthoquine 41 7.0 (5.5-8.8) 44 4.2 (3.1-5.8) 0.015
Lumefantrine 25 2.4 (1.8-3.1) 47 1.5 (1.1-2.1) 0.075
Dihydroartemisinin 30 2.1 (1.5-2.9) 50 5.2 (4.2-6.5) <0.001
  1. Data are geometric mean and (95% CI) and P-values are two-tailed from Student’s t-test.