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Table 1 Antiplasmodial activity, Cytotoxicity and selectivity of methanol (M) and ethyl acetate (EA) extracts of selected medicinal plants

From: Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats

Sr No. Name of the plants Parts and Solvent of Extraction M-Methanol EA-Ethyl acetate Yields (%) P. falciparum IC 50 (μg/mL) Cytotoxicity (TC 50 μg/mL) against HeLa cell line
3D7 INDO
1 Aerva lanata Whole aerial EA 15.4 17 8 (0.47)* 77 (9.63)#
2 Anisomeles malabarica Leaf M   >100 - -
Leaf EA   16 16 (1) 48 (3)#
3 Anogeissus latifolia Bark EA 12.5 8 4.5(0.56) >100 (>22)
4 Cardiospermum halicacabum Leaves EA 10.2 42 - -
5 Cassia alata Leaves EA 14.1 18 20 (1.11) 100 (5)
6 Couroupita guianensis Leaves EA 7.6 39 - -
7 Euphorbia hirta Leaves EA 9.6 21 - -
8 Gloriosa superba Flower M   >100 - -
Flower EA   62 - -
9 Glycyrrhiza glabra Root EA 13.2 6 4.5 (0.75) 22 (4.89)
10 Indigofera tinctoria Leaves EA 8.5 57 - -
11 Juglans regia Seed M   20 12.5 (0.625) >100 (>8)
Seed EA   >100 - -
12 Pergularia daemia Leaves EA 12.9 21 - -
13 Psidium guajava Leaf M   15 9 (0.6) 68 (4.6)
Leaf EA   12.5 18 (1.4) 82 (6.6)
14 Ricinus communis Leaf M   34 - -
Leaf EA   57.5 - -
Seed M   30 - -
Seed EA   100 - -
15 Solanum xanthocarpum Whole aerial EA 11.6 17 7 (0.41 ) 75 (10.7)
16 Tinospora cordifolia Leaves EA 6.8 31 - -
17 Tridax procumbens Leaf M   62 - -
Leaf EA   32 - -
  Chloroquine    0.021 0.258 (12.28) >200
  Artemisinin    0.0045 0.0045 (1) >200
  1. (−) not tested, *values in parentheses represent resistance indices (IC50 INDO/IC50 3D7), #values in parentheses represent selectivity indices (TC50 HeLa/IC50INDO).