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Table 2 Robustness results for chloroquine and primaquine obtained by HPLC method

From: Simultaneous quantitation of chloroquine and primaquine by UPLC-DAD and comparison with a HPLC-DAD method

Conditions

Chloroquine

Primaquine

Mean content (%)

R.S.D. (%)

Retention time (min)

Mean content (%)

R.S.D. (%)

Retention time (min)

Nominal*

99.59

0.90

2.58

99.77

0.11

2.92

Acetonitile concentration 8-38%

99.92

0.77

2.60

99.82

0.56

3.10

Acetonitile concentration 12-42%

99.49

1.10

2.56

99.68

0.60

2.77

Mobile phase pH 2.7

99.80

1.46

2.58

100.22

1.28

2.87

Mobile phase pH 3.3

100.06

1.65

2.58

100.02

1.31

2.97

Temperature 23°C

99.31

0.67

2.60

99.84

0.17

2.93

Temperature 27°C

99.63

1.13

2.59

99.87

0.26

2.92

  1. *Acetonitrile concentration in gradient 10-40%, mobile phase pH 3.0, temperature 25°C.
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Malaria Journal

ISSN: 1475-2875

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