Table 3 Ex vivo susceptibility of Plasmodium falciparum isolates to chloroquine, dihydroartemisinin, pyronaridine and piperaquine (standard and modified protocols)
From: Drying anti-malarial drugs in vitro tests to outsource SYBR green assays
Culture success rate (n/N) | Standard protocol | Modified protocol | P | |
|---|---|---|---|---|
IC 50 mean (nM) [95% CI] | IC 50 mean (nM) [95% CI] | |||
CQ | 66.6% (6/9) | 484.08 [176-791] | 730.66 [595-995] | 0.35 |
DHA | 66.6% (6/9) | 1.67 [1.21-2.12] | 1.44 [0.88-2] | 0.55 |
PYD | 55.5% (5/9) | 14.23 [2.83-25.63] | 16.85 [1.69-32] | 0.79 |
PPQ | 55.5% (5/9) | 78.22 [36.56-119.87] | 74 [24.61-123.38] | 0.90 |