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Figure 3 | Malaria Journal

Figure 3

From: Cytokine and chemokine profile of the innate and adaptive immune response of schistosoma haematobium and plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon

Figure 3

Effect of P. falciparum and S. haematobium single infection or coinfection on the levels of the principal components reflecting the innate immune response of the study subjects. Two principal components (iPC1 and iPC2) were identified and explained 67% of the variance in the database. The iPC1 was made of almost all the cytokine included in the model and thus was representative of the innate immune responsiveness of the study subjects. The iPC2, in contrast, was formed by 4 cytokines who clustered into two groups MCP1-MCAF and MIP1b positively loaded in the iPC2 and INFγ and TNF that were negatively loaded. Thus an increase of the iPC2 will mirror an increase of the positively loaded chemokines and a decrease of the negatively loaded cytokines. The box plots represent the median and the interquartile range of the different iPCs while the whiskers show the minimal and maximal value.

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Malaria Journal

ISSN: 1475-2875

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