Table 1 In vitro anti-malarial activities (IC 50 and IC 90 ) of 10 anti-malaria compounds against the P. falciparum NF54 cell bank parasites
Compound | Maximal concentration tested (nM) | IC 50 (nM) | IC 90 (nM) | ||
|---|---|---|---|---|---|
Average (n = 2) | Standard deviation (n = 2) | Average (n = 2) | Standard deviation (n = 2) | ||
Artemether | 50 | 5.9 | 1.7 | 9.9 | 2.4 |
Artesunate | 50 | 3.3 | 0.2 | 6.0 | 0.4 |
Dihydroartemisinin | 35 | 2.5 | 0.1 | 5.0 | 0.6 |
Atovaquone | 25 | 0.22 | 0.06 | 1.3 | 0.5 |
Mefloquine | 728 | 45 | 6 | 85 | 13 |
Piperaquine | 200 | 19 | 6 | 28 | 9 |
Lumefantrine | 800 | 118 | 14 | 318 | 166 |
Chloroquine | 250 | 11.2 | 1.4 | 14.7 | 2.0 |
Pyrimethamine | 50 | 0.57 | 0.04 | 1.28 | 0.15 |
Proguanil | 200,000 | 292 | 20 | 1,335 | 504 |