Table 1 IC 50 values for individual compounds
From: Novel pantothenate derivatives for anti-malarial chemotherapy
| Â | Anti-malarial activity | Anti-vanin activity* | |
|---|---|---|---|
Compound | IC 50 (μM) | 95% C.I. (μM) | IC 50 (μM) |
Pantothenol | >100 | NA | NT |
CJ-15,801 | >100 | NA | 213.60 |
SN 12,601 | 6.1 | 4.5-8.7 | 17.61 |
SN 14,621 | 33.6 | 7.3-NA | 33.70 |
SN 14,622 | 7.4 | 3.5-20.7 | 31.89 |
CXP14.1-034 | 24.1 | 11.3-NA | 1.69 |
CXP14.1-060 | >100 | NA | 0.039 |
RR2 | 2.6 | 2.1-3.3 | 2.85 |
RR6 | 14.5 | 5.3-NA | 0.04 |
RR7 | 7.7 | 5.1-12.6 | 0.11 |
RR8 | 2.2 | 1.6-3.1 | 0.27 |
N5-Pan | 45.1 | 34.8-60.2 | NT |
N7-Pan | 79.0 | 34.0-NA | NT |
N9-Pan | 14.6 | 11.0-20.1 | NT |
Phenethyl-Pan | 98.2 | NA | NT |