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Table 1 IC 50 values for individual compounds

From: Novel pantothenate derivatives for anti-malarial chemotherapy

  Anti-malarial activity Anti-vanin activity*
Compound IC 50 (μM) 95% C.I. (μM) IC 50 (μM)
Pantothenol >100 NA NT
CJ-15,801 >100 NA 213.60
SN 12,601 6.1 4.5-8.7 17.61
SN 14,621 33.6 7.3-NA 33.70
SN 14,622 7.4 3.5-20.7 31.89
CXP14.1-034 24.1 11.3-NA 1.69
CXP14.1-060 >100 NA 0.039
RR2 2.6 2.1-3.3 2.85
RR6 14.5 5.3-NA 0.04
RR7 7.7 5.1-12.6 0.11
RR8 2.2 1.6-3.1 0.27
N5-Pan 45.1 34.8-60.2 NT
N7-Pan 79.0 34.0-NA NT
N9-Pan 14.6 11.0-20.1 NT
Phenethyl-Pan 98.2 NA NT
  1. *Anti-vanin activity tested in human serum.
  2. NA: Not Applicable.
  3. NT: Not Tested.