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Table 3 Stability of LUME and 97–63 in rat plasma

From: Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study

  LUME 97-63
  Mean a SD Precision b (%) Accuracy c (%) Mean a SD Precision b (%) Accuracy c (%)
10 (ng/mL)         
0 hr (for all) 9.6 0.22 2.24 96.20 10.2 0.46 4.54 109.12
24 hrs (AS) 9.9 0.40 4.05 103.72 4.3 0.16 3.74 104.67
6 hrs (BT) 9.8 0.69 7.01 101.73 3.8 0.16 4.30 93.85
FT-3 9.6 0.74 7.74 99.48 3.9 0.13 3.34 98.16
15 days at −70°C 9.6 0.24 2.49 105.73 4.1 0.12 2.92 100.47
400 (ng/mL)         
0 hr (for all) 387.3 16.61 4.29 96.83 405.2 14.16 3.50 101.29
24 hrs (AS) 393.2 17.62 4.48 101.51 407.0 16.16 3.97 100.45
6 hrs (BT) 391.3 19.01 4.86 101.03 388.3 14.47 3.73 95.85
FT-3 413.5 12.34 2.98 106.78 404.3 6.15 1.52 99.79
15 days at −70°C 397.2 9.28 2.34 102.54 400.0 8.34 2.09 98.72
  1. a Back calculated plasma concentrations (n = 6).
  2. b Expressed as % RSD = (SD/mean) × 100.
  3. c Calculated as (mean determined concentration/nominal concentration) × 100.