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Table 3 Stability of LUME and 97–63 in rat plasma

From: Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study

 

LUME

97-63

 

Mean a

SD

Precision b (%)

Accuracy c (%)

Mean a

SD

Precision b (%)

Accuracy c (%)

10 (ng/mL)

        

0 hr (for all)

9.6

0.22

2.24

96.20

10.2

0.46

4.54

109.12

24 hrs (AS)

9.9

0.40

4.05

103.72

4.3

0.16

3.74

104.67

6 hrs (BT)

9.8

0.69

7.01

101.73

3.8

0.16

4.30

93.85

FT-3

9.6

0.74

7.74

99.48

3.9

0.13

3.34

98.16

15 days at −70°C

9.6

0.24

2.49

105.73

4.1

0.12

2.92

100.47

400 (ng/mL)

        

0 hr (for all)

387.3

16.61

4.29

96.83

405.2

14.16

3.50

101.29

24 hrs (AS)

393.2

17.62

4.48

101.51

407.0

16.16

3.97

100.45

6 hrs (BT)

391.3

19.01

4.86

101.03

388.3

14.47

3.73

95.85

FT-3

413.5

12.34

2.98

106.78

404.3

6.15

1.52

99.79

15 days at −70°C

397.2

9.28

2.34

102.54

400.0

8.34

2.09

98.72

  1. a Back calculated plasma concentrations (n = 6).
  2. b Expressed as % RSD = (SD/mean) × 100.
  3. c Calculated as (mean determined concentration/nominal concentration) × 100.
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Malaria Journal

ISSN: 1475-2875

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