Antigenicity and immunogenicity of PvRALP1, a novel Plasmodium vivax rhoptry neck protein

Malaria Journal

Table 1 Prevalence (% positive), 95% confidence intervals, and mean fluorescence intensity of IgG responses to Plasmodium vivax RALP1-Ecto and RALP1-Tr in sera from human P. vivax patients and healthy individuals

RALP1	No. of patient samples ( n )			95% CI ^b	MFI (%)	No. of healthy individuals ( n )			95% CI	MFI (%)	P -value ^d
	Positive	Negative	Total (%) ^a			Positive	Negative	Total (%) ^c
Ecto	66	46	112 (58.9)	49.67–67.6	14138	4	76	80 (5.0)	87.54–97.99	5032	p < 0.0001
Tr	62	50	112 (55.4)	46.13–64.23	8757	6	74	80 (7.5)	84.59–96.52	3047	p < 0.0001

MFI = mean fluorescence intensity.
^aSensitivity: % positive in patient samples.
^bConfidence intervals.
^cSpecificity: % negative control healthy samples.
^dDifferences in the total IgG prevalence for each antigen between P. vivax patients and healthy individuals were calculated with Student’s t-test. P < 0.05 was considered significant.

ISSN: 1475-2875