Skip to main content

Table 4 Prevalence of mutations Plasmodium falciparum dihydrofolate reductase ( dhfr ) and dihydropteroate synthase ( dhps ) mutations associated with resistance to sulphadoxine-pyrimethamine detected at day 0

From: In vivo efficacy of sulphadoxine-pyrimethamine for the treatment of asymptomatic parasitaemia in pregnant women in Machinga District, Malawi

Mutation Mutant (n)/Total (N) Per cent mutant
dhfr N51I 209/212 99%
dhfr C59R 210/214 98%
dhfr S108N 211/214 99%
dhfr I164L 2/211 1%
dhps A437G 219/225 97%
dhps K540E 201/204 99%
dhps A581G 4/204 2%
dhps A613T/S 2/180 1%
Double* 187/193 97%
Triple* 196/202 97%
Quintuple* 172/182 95%
  1. *Double mutant = Pfdhps mutations A437G and G540E; Triple mutant = Pfdhfr mutations N51I, C59R and S108N; Quintuple mutant = Pfdhfr mutations N51I, C59R, S108N and Pfdhps mutations A437G and K540E.