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Table 4 Prevalence of mutations Plasmodium falciparum dihydrofolate reductase ( dhfr ) and dihydropteroate synthase ( dhps ) mutations associated with resistance to sulphadoxine-pyrimethamine detected at day 0

From: In vivo efficacy of sulphadoxine-pyrimethamine for the treatment of asymptomatic parasitaemia in pregnant women in Machinga District, Malawi

Mutation

Mutant (n)/Total (N)

Per cent mutant

dhfr N51I

209/212

99%

dhfr C59R

210/214

98%

dhfr S108N

211/214

99%

dhfr I164L

2/211

1%

dhps A437G

219/225

97%

dhps K540E

201/204

99%

dhps A581G

4/204

2%

dhps A613T/S

2/180

1%

Double*

187/193

97%

Triple*

196/202

97%

Quintuple*

172/182

95%

  1. *Double mutant = Pfdhps mutations A437G and G540E; Triple mutant = Pfdhfr mutations N51I, C59R and S108N; Quintuple mutant = Pfdhfr mutations N51I, C59R, S108N and Pfdhps mutations A437G and K540E.
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Malaria Journal

ISSN: 1475-2875

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