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Table 1 Investigations

From: Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury

Parameter

Day 0

Day 3

Day 14

Day 20

Day 44

Normal range

Plasma haemoglobin (ng/mL)a

177,839

–

–

127,146

–

<124,000

Haemoglobin (g/L)

141

136

60

49

102

140–180

Haematocrit (%)

43.6

40

18.7

16

27.1

47–54

Mean corpuscule volume (fL)

86.3

–

86.2

94.7

85.2

76–96

Plasma haptoglobin (μg/mL)a

1,160

–

–

5

–

300–2,000

Platelets (×103/μL)

28

–

228

478

320

150–00

White blood cells (×103/μL)

6.23

–

19.9

9.8

10.5

4–10

Neutrophils (%)

83

 

–

70

60

40–70

Creatinine (μmol/L)

97

86

–

1,769

132

53–115

Potassium (μmol/L)

3.7

4.4

–

8.4

4.8

3.5–4.9

Venous pH

7.41

–

–

7.2

–

7.31–7.41

Venous bicarbonate (mmol/L)

19.5

–

–

8.7

–

23–28

Venous carbon dioxide (mmHg)

31.2

–

–

23.5

–

41–51

Venous base excess (mmol/L)

−5

–

–

−20

–

(−2) to (+3)

Venous lactate (mmol/L)

2.36

–

–

0.58

–

0.9–1.7

Anion gap (mmol/L)

13

–

–

6

–

10–20

Total bilirubin (μmol/L)

80

–

–

–

–

3–21

Indirect bilirubin (μmol/L)

26

–

–

–

–

2–14

Lactate dehydrogenase (U/L)

592

–

–

887

–

140–280

International normalization ratio

–

1.3

–

–

–

0.8–1.2

Partial thromboplastin time (seconds)

–

15

–

–

–

<30

  1. aSpecialized tests performed on samples sent to Darwin, Australia.