Table 2 Associations between TNF genotype and rates of first and all episodes of malaria

rs1799964

−1031TT

−1031TC

−1031CC

 All episodes of malaria

  n

356

200

25

  Incidence

2.93

(907/309.1)

2.92

(502/171.9)

4.15

(90/21.7)

  Hazard ratio, crude

1.00

Reference

0.99

[0.85–1.14]

1.41

[1.01–1.97]

  Hazard ratio, adjusted^a

1.00

Reference

0.95

[0.82–1.09]

1.35

[1.01–1.80]

 First episode of malaria

  Incidence

2.85

(296/104.0)

3.09

(168/54.4)

3.29

(20/6.07)

  Incidence ratio

1.00

Reference

1.08

[0.89–1.31]

1.15

[0.68–1.76]

  Hazard ratio, crude

1.00

Reference

1.08

[0.90–1.31]

1.17

[0.90–1.31]

  Hazard ratio, adjusted^a

1.00

Reference

1.07

[0.89–1.31]

1.11

[0.66–1.86]

rs1800629

−308GG

−308GA

−308AA

 All episodes of malaria

  n

477

104

3

  Incidence

2.97

(1216/409.2)

3.08

(282/91.5)

0.36

(1/2.8)

  Hazard ratio, crude

1.00

Reference

1.04

[0.87–1.24]

0.13

[0.02–0.63]

  Hazard ratio, adjusted^a

1.00

Reference

1.10

[0.93–1.29]

0.14

[0.04–0.48]

 First episode of malaria

  Incidence

2.89

(392/135.6)

3.27

(91/27.8)

0.53

(1/1.9)

  Incidence ratio

1.00

Reference

1.13

[0.90–1.44]

0.18

[0.00–0.98]

  Hazard ratio, crude

1.00

Reference

1.07

[0.86–1.33]

0.27

[0.03–2.86]

  Hazard ratio, adjusted^a

1.00

Reference

1.14

[0.91–1.44]

0.33

[0.03–3.59]