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Table 8 Activity of Vernonia amygdalina extracts, fractions and pure compounds on cell viability of a human colon cancer and endothelial cell line

From: Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds

Test agents IC50 (95% CI)
HCT116 EA.hy 926
Leaf extracts (μg/mL)
 Ver-EtOH 3.66 (3.41–3.96) 9.46 (8.64–10.36)
 Ver-MeOH 8.09 (7.54–8.67) 16.94 (15.55–18.46)
 Ver-H2O 64.34 (58.75–70.53) 76.21 (58.09–100.00)
Fractions from methanol extract (μg/mL)
 Fraction 11 0.17 (0.15–0.18) 0.42 (0.39–0.45)
 Fraction 12 0.33 (0.3–0.37) 1.13 (0.97–1.31)
 Fraction 13 2.41 (2.29–2.53) 4.52 (4.23–4.82)
 Fraction 14 3.86 (3.62–4.12) 7.69 (7.10–8.32)
Molecules from fractions (μM)
 Vernolide 1.49 (1.38–1.61) 3.18 (2.97–3.4)
 Vernodalol 4.97 (4.78–5.17) 7.1 (6.51–7.74)
  1. Each value represents the mean of two experiments carried out in quadruplet wells.
  2. Ver-EtOH, Ver-MeOH, and Ver-H2O stands for ethanolic, methanolic and aqueous extract of V. amygdalina leaves.
  3. HCT 116 human colon carcinoma cell line, EA.hy 926 human (non-tumour) endothelial cell line, 95% CI 95% confidence interval.