Table 8 Activity of Vernonia amygdalina extracts, fractions and pure compounds on cell viability of a human colon cancer and endothelial cell line
From: Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds
Test agents | IC50 (95% CI) | |
|---|---|---|
HCT116 | EA.hy 926 | |
Leaf extracts (μg/mL) | ||
 Ver-EtOH | 3.66 (3.41–3.96) | 9.46 (8.64–10.36) |
 Ver-MeOH | 8.09 (7.54–8.67) | 16.94 (15.55–18.46) |
 Ver-H2O | 64.34 (58.75–70.53) | 76.21 (58.09–100.00) |
Fractions from methanol extract (μg/mL) | ||
 Fraction 11 | 0.17 (0.15–0.18) | 0.42 (0.39–0.45) |
 Fraction 12 | 0.33 (0.3–0.37) | 1.13 (0.97–1.31) |
 Fraction 13 | 2.41 (2.29–2.53) | 4.52 (4.23–4.82) |
 Fraction 14 | 3.86 (3.62–4.12) | 7.69 (7.10–8.32) |
Molecules from fractions (μM) | ||
 Vernolide | 1.49 (1.38–1.61) | 3.18 (2.97–3.4) |
 Vernodalol | 4.97 (4.78–5.17) | 7.1 (6.51–7.74) |