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Table 1 Calculating G6PD activity

From: The challenges of introducing routine G6PD testing into radical cure: a workshop report

The WHO has defined a total of five classes (I–V) of G6PD activity [16]:
 • Severe deficiency (<10 % activity, chronic, non-spherocytic, haemolytic anaemia)
 • Severe deficiency (<10 % activity, intermittent haemolysis)
 • Mild deficiency (10–60 % activity, haemolysis with stressors only)
 • Normal enzyme variant (60–150 % activity, no clinical sequelae)
 • Increased enzyme activity (>150 % activity, no clinical sequelae)
100 % G6PD activity is based on the adjusted quantitative (iU/gHb or U/1012 RBC) median of all male samples from a defined sample set [9]. In a first step the median G6PD activity of samples from all male participants is calculated. Second, all samples with ≤10 % G6PD activity of the median are excluded. Third, the median is re-calculated based on the remaining samples, the adjusted male median. The adjusted male median is defined as 100 % G6PD activity and all samples are grouped accordingly